Analysis of transcript and methylation levels of INSL3 and RXFP2 in undescended and descended dog testes suggested promising biomarkers associated with cryptorchidism.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.08.029
Abstract: Cryptorchidism is the most common disorder of sex development (DSD) in dogs. This malformation is associated with reduced fertility and with a higher risk of gonadal cancer. Testicular descent is a complex process, and the… read more here.
Keywords: cryptorchidism; insl3 rxfp2; rxfp2; levels insl3 ... See more keywords
Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates.
Sign Up to like & getrecommendations! Published in 2020 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2020.113583
Abstract: Although the insulin-like peptide hormone INSL3 and its cognate receptor RXFP2 (relaxin-family peptide receptor 2) have existed throughout chordate evolution, their physiological diversification appears to be linked closely with mammalian emergence and radiation. In contrast,… read more here.
Keywords: evolution; insl3 rxfp2; insl3; physiology ... See more keywords
Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction"
DOI: 10.1093/humrep/dead105
Abstract: STUDY QUESTION What is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility? SUMMARY ANSWER Bi-allelic loss-of-function (LoF) variants in… read more here.
Keywords: cryptorchidism; insl3 rxfp2; variants insl3; bilateral cryptorchidism ... See more keywords