A new immunohistochemical marker, insulinoma-associated protein 1 (INSM1), for Merkel cell carcinoma: Evaluation of 24 cases.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2019.04.002
Abstract: Merkel cell carcinoma (MCC) is an uncommon primary neuroendocrine carcinoma of the skin. Nowadays, pathologists are required to perform immunohistochemistry to demonstrate neuroendocrine and epithelial differentiation for diagnosis of MCC. Insulinoma-associated protein 1 (INSM1) is… read more here.
Keywords: carcinoma; cell carcinoma; insm1; marker ... See more keywords
142 Medullary Carcinoma or Neuroendocrine component? The INSM1 Dilemma in Colonic Neoplasia
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaf121.127
Abstract: Insulinoma-associated protein 1 (INSM1) is a highly sensitive marker for neuroendocrine differentiation. However, emerging reports show it may be expressed in non-neuroendocrine malignancies and can be a diagnostic pitfall. The purpose of this report is… read more here.
Keywords: carcinoma neuroendocrine; carcinoma; 142 medullary; insm1 ... See more keywords
Insulinoma-associated protein 1 controls nasopharyngeal carcinoma to radiotherapy by modulating cyclin D1-dependent DNA repair machinery.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz101
Abstract: Insulinoma-associated protein 1 (INSM1), a zinc finger transcriptional factor, is proven to be deregulated in several types of cancers. However, comprehension of the molecular mechanism of INSM1-mediated tumor progression remains poor. Here, we show that… read more here.
Keywords: repair machinery; dna repair; cyclin dependent; insm1 ... See more keywords
PD59-01 INSM1 IS A DRIVER OF NEUROENDOCRINE PROSTATE CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000969.01
Abstract: INTRODUCTION AND OBJECTIVE: Neuroendocrine prostate cancer (NEPC), arising mostly from adenocarcinoma via NE transdifferentiation following androgen deprivation therapy, is a lethal subtype of prostate cancer (PCa). Mechanisms contributing to NEPC development and its aggressiveness remain… read more here.
Keywords: nepc; insm1; prostate; neuroendocrine prostate ... See more keywords
Comparative performance of insulinoma‐associated protein 1 (INSM1) and routine immunohistochemical markers of neuroendocrine differentiation in the diagnosis of endocrine mucin‐producing sweat gland carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.13831
Abstract: Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal malignancy with predilection for the eyelids of older adults. It must be distinguished from metastatic adenocarcinomas of extracutaneous origin and from benign adnexal proliferations… read more here.
Keywords: mucin producing; mucin; diagnosis; producing sweat ... See more keywords
Comparison of insulinoma-associated protein 1 (INSM1) with traditional neuroendocrine markers in gastrointestinal and pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs)
Sign Up to like & getrecommendations! Published in 2024 at "Diagnostic Pathology"
DOI: 10.1186/s13000-024-01568-0
Abstract: The traditional diagnostic markers for mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are synaptophysin (SYP), chromogranin A (CHGA) and CD56. However, there is still a lack of a large series of article focused on the expression of insulinoma-associated… read more here.
Keywords: gastrointestinal pancreatic; neuroendocrine non; chga; insm1 ... See more keywords
Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass
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DOI: 10.2337/db17-1330
Abstract: Baseline β-cell mass is established during the early postnatal period when β-cells expand. In this study, we show that heterozygous ablation of Insm1 decreases baseline β-cell mass and subsequently impairs glucose tolerance. When exposed to… read more here.
Keywords: baseline cell; cell; cell mass; insm1 ... See more keywords
Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11101376
Abstract: Simple Summary Neuroblastoma (NB) is a cancer that starts in certain very early forms of nerve cells of the sympathetic nervous system, most often found in an embryo or fetus. Symptoms may include bone pain,… read more here.
Keywords: insm1; role; insm1 myc; expression ... See more keywords
Immunosensitivity and specificity of insulinoma-associated protein 1 (INSM1) for neuroendocrine neoplasms of the uterine cervix
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gynecologic Oncology"
DOI: 10.3802/jgo.2023.34.e1
Abstract: Objective Previously, we reported that insulinoma-associated protein 1 (INSM1) immunohistochemistry (IHC) showed high sensitivity for neuroendocrine carcinoma of the uterine cervix and was an effective method for histopathological diagnosis, but that its specificity remained to… read more here.
Keywords: insm1; cell; specificity; insulinoma associated ... See more keywords