Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer's Disease Therapy.
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DOI: 10.1021/acs.nanolett.2c00191
Abstract: The inflammatory dysfunction of microglia from excess amyloid-β peptide (Aβ) disposal is an overlooked but pathogenic event in Alzheimer's disease (AD). Here, we exploit a native high-density lipoprotein (HDL)-inspired nanoscavenger (pHDL/Cur-siBACE1) that combines the trinity… read more here.
Keywords: pronged modulation; microglial dysfunction; alzheimer disease; inspired nanoscavenger ... See more keywords