Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models
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DOI: 10.1007/s00125-018-4606-2
Abstract: Aims/hypothesisBi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have been shown to activate two mutant receptors,… read more here.
Keywords: insulin; insulin receptor; insr; insulin receptoropathy ... See more keywords
Changes in the Metastatic Properties of MDA-MB-231 Cells after IGFBP6 Gene Knockdown Is Associated with Increased Expression of miRNA Genes Controlling INSR, IGF1R, and CCND1 Genes
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DOI: 10.1007/s10517-019-04409-z
Abstract: Metastatic cascade is associated with the process of epithelial-mesenchymal transition accompanied by changes in cell proliferation, migration, adhesion, and invasiveness mediated by the insulin-like growth factor (IGF) signal pathway. IGFBP6 protein binds IGF and prevents… read more here.
Keywords: igfbp6 gene; mda 231; gene knockdown; insr ... See more keywords
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
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DOI: 10.1038/s41467-022-28039-8
Abstract: Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an Ins1 cre knock-in allele to… read more here.
Keywords: mice; insulin resistance; insulin; cell ... See more keywords
Mechanism of INSR clustering with insulin activation and resistance revealed by super-resolution imaging.
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DOI: 10.1039/d2nr01051h
Abstract: Insulin receptor (INSR) is a key protein in the INSR signaling pathway and plays a critical role in biological processes, especially in the regulation of glucose homeostasis. Many metabolic diseases are often accompanied by abnormal… read more here.
Keywords: insulin resistance; super resolution; resistance; insr ... See more keywords
Transcriptional Regulation of INSR, the Insulin Receptor Gene
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DOI: 10.3390/genes10120984
Abstract: The insulin receptor gene encodes an evolutionarily conserved signaling protein with a wide spectrum of functions in metazoan development. The insulin signaling pathway plays key roles in processes such as metabolic regulation, growth control, and… read more here.
Keywords: insulin; insulin receptor; insr; receptor gene ... See more keywords