Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models
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DOI: 10.1007/s00125-018-4606-2
Abstract: Aims/hypothesisBi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have been shown to activate two mutant receptors,… read more here.
Keywords: insulin; insulin receptor; insr; insulin receptoropathy ... See more keywords
Changes in the Metastatic Properties of MDA-MB-231 Cells after IGFBP6 Gene Knockdown Is Associated with Increased Expression of miRNA Genes Controlling INSR, IGF1R, and CCND1 Genes
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DOI: 10.1007/s10517-019-04409-z
Abstract: Metastatic cascade is associated with the process of epithelial-mesenchymal transition accompanied by changes in cell proliferation, migration, adhesion, and invasiveness mediated by the insulin-like growth factor (IGF) signal pathway. IGFBP6 protein binds IGF and prevents… read more here.
Keywords: igfbp6 gene; mda 231; gene knockdown; insr ... See more keywords
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
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DOI: 10.1038/s41467-022-28039-8
Abstract: Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an Ins1 cre knock-in allele to… read more here.
Keywords: mice; insulin resistance; insulin; cell ... See more keywords
Mechanism of INSR clustering with insulin activation and resistance revealed by super-resolution imaging.
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DOI: 10.1039/d2nr01051h
Abstract: Insulin receptor (INSR) is a key protein in the INSR signaling pathway and plays a critical role in biological processes, especially in the regulation of glucose homeostasis. Many metabolic diseases are often accompanied by abnormal… read more here.
Keywords: insulin resistance; super resolution; resistance; insr ... See more keywords
#662 The DNA methyltransferase inhibitor 5-azacytidine alleviates podocyte injury by reversing DNA hypermethylation-mediated inhibition of INSR in podocytes of diabetic db/db mice
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DOI: 10.1093/ndt/gfaf116.0382
Abstract: The downregulation of the insulin receptor (INSR) in podocytes, leading to insulin resistance, is an important cause of diabetic kidney disease (DKD) podocyte damage. However, the mechanism is unclear. Our previous studies have shown that… read more here.
Keywords: podocyte injury; insr podocytes; dna methylation; insr ... See more keywords
Transcriptional Regulation of INSR, the Insulin Receptor Gene
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DOI: 10.3390/genes10120984
Abstract: The insulin receptor gene encodes an evolutionarily conserved signaling protein with a wide spectrum of functions in metazoan development. The insulin signaling pathway plays key roles in processes such as metabolic regulation, growth control, and… read more here.
Keywords: insulin; insulin receptor; insr; receptor gene ... See more keywords