Inceptor counteracts insulin signalling in β-cells to control glycaemia.
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DOI: 10.1038/s41586-021-03225-8
Abstract: Resistance to insulin and insulin-like growth factor 1 (IGF1) in pancreatic β-cells causes overt diabetes in mice; thus, therapies that sensitize β-cells to insulin may protect patients with diabetes against β-cell failure1-3. Here we identify… read more here.
Keywords: receptor; insulin; insr igf1r; inceptor ... See more keywords
The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
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DOI: 10.3390/biom11040531
Abstract: Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively. Evidence accumulated in recent years indicates that, in addition to their typical cell-surface localization pattern and… read more here.
Keywords: insulin; insr igf1r; insulin igf1; igf1r ... See more keywords