Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104074
Abstract: Summary Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify… read more here.
Keywords: instability drives; drives convergent; convergent divergent; chromosomal instability ... See more keywords
A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches
Sign Up to like & getrecommendations! Published in 2021 at "Nature Physics"
DOI: 10.1038/s41567-020-01141-8
Abstract: Liquid–liquid phase separation1,2 occurs not only in bulk liquid, but also on surfaces. In physiology, the nature and function of condensates on cellular structures remain unexplored. Here we study how the condensed protein TPX2 behaves… read more here.
Keywords: microtubule; instability; drives protein; hydrodynamic instability ... See more keywords