Assessing phenotypic effect of integrase strand-transfer inhibitor (INSTI)-based resistance substitutions associated with failures on cabotegravir
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaf019
Abstract: Abstract Objectives International guidelines recommend integrase strand-transfer inhibitor (INSTI)-based regimens as initial and switch therapy in people with HIV. As novel INSTIs become available, understanding how emergence of resistance at virological failures and seroconversions affects… read more here.
Keywords: resistance; insti; integrase strand; bictegravir elvitegravir ... See more keywords
Risk of immune reconstitution inflammatory syndrome with integrase inhibitors versus other classes of antiretrovirals: a systematic review and meta-analysis of randomised trials.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002937
Abstract: BACKGROUND Integrase strand transfer inhibitors (InSTIs) decrease HIV plasma viral load faster than other antiretroviral classes. More rapid viral load decline has been associated with higher risk of immune reconstitution inflammatory syndrome (IRIS). There are… read more here.
Keywords: meta analysis; risk immune; risk; iris ... See more keywords
Socioeconomic status largely explains integrase inhibitors-related body composition differences in chronically infected men living with HIV
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral Therapy"
DOI: 10.1177/13596535221109748
Abstract: Background Substantial body composition alterations have been reported after starting combined antiretroviral therapy (cART). We characterized a cohort of chronically infected and virologically suppressed (VL < 50 copies/ml) men (≥50 years old) living with HIV… read more here.
Keywords: insti; living hiv; body composition; body ... See more keywords
Durability of switch regimens based on rilpivirine or on integrase inhibitors, both in association with tenofovir and emtricitabine, in HIV-infected, virologically suppressed patients
Sign Up to like & getrecommendations! Published in 2017 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-017-2831-9
Abstract: BackgroundSwitch strategies based on rilpivirine/tenofovir/emtricitabine or on an integrase inhibitor (InSTI) plus tenofovir/emtricitabine have never been compared in randomized clinical trials. The main aim of the study was to investigate the durability of these two… read more here.
Keywords: tenofovir emtricitabine; hiv; group; durability ... See more keywords
Integrase Inhibitor-Based Antiretroviral Therapy Among Women Living with HIV: Data from the OPERA Cohort.
Sign Up to like & getrecommendations! Published in 2019 at "Current HIV research"
DOI: 10.2174/1570162x17666190927161537
Abstract: BACKGROUND Women face unique complexities in HIV treatment yet are underrepresented in antiretroviral therapy (ART) studies. OBJECTIVE This analysis assessed one-year durability of the first integrase strand transfer inhibitor (INSTI)-based regimens prescribed to women in… read more here.
Keywords: living hiv; treatment; cohort; dtg ... See more keywords
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1.
Sign Up to like & getrecommendations! Published in 2022 at "Current HIV research"
DOI: 10.2174/1570162x20666220303104509
Abstract: BACKGROUND AND OBJECTIVE Integrase strand transfer inhibitors (INSTIs) are currently the standard of practice for first-line HIV therapy for most patients. We evaluated the mutations associated with INSTI resistance in naive HIV-1 infected patients and… read more here.
Keywords: insti free; insti; integrase strand; resistance ... See more keywords
Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1482348
Abstract: Background We evaluated the prevalence of archived proviral drug resistance mutations (DRMs) associated with resistance to integrase strand transfer inhibitors (INSTIs) shortly before Botswana transitioned in 2016 to using dolutegravir (DTG)-based antiretroviral treatment in first-line… read more here.
Keywords: resistance; prevalence archived; insti; first line ... See more keywords