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   Articles with "insulin" as a keyword



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Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin.

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recommendations! Published in 2021 at "JAMA internal medicine"

DOI: 10.1001/jamainternmed.2020.9176

Abstract: Importance Previous studies have found that the risk of severe hypoglycemia does not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes. However, these studies did not… read more here.

Keywords: insulin; risk; long acting; hypoglycemia ... See more keywords

Efficacy and Safety of Enteral Recombinant Human Insulin in Preterm Infants: A Randomized Clinical Trial.

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recommendations! Published in 2022 at "JAMA pediatrics"

DOI: 10.1001/jamapediatrics.2022.0020

Abstract: Importance Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears to promote intestinal maturation. The insulin concentration in human milk declines rapidly post partum and… read more here.

Keywords: group; preterm infants; median iqr; insulin ... See more keywords

The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14369

Abstract: Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this… read more here.

Keywords: aggregation; toxicity; structure toxicity; unsaturation fatty ... See more keywords

Phosphorylation of TG‐interacting factor 1 at carboxyl‐terminal sites in response to insulin regulates adipocyte differentiation

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14849

Abstract: TG‐interacting factor 1 (TGIF1) contributes to the differentiation of murine white preadipocyte and human adipose tissue‐derived stem cells; however, its regulation is not well elucidated. Insulin is a component of the adipogenic cocktail that induces… read more here.

Keywords: adipocyte differentiation; insulin; tgif1; interacting factor ... See more keywords

Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3‐L1 preadipocytes

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13516

Abstract: Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and… read more here.

Keywords: 3t3 preadipocytes; insulin signaling; receptor; gpr50 ... See more keywords

Beta cell regeneration upon magainin and growth hormone treatment as a possible alternative to insulin therapy

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recommendations! Published in 2023 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13556

Abstract: Insulin therapy, pancreas transplantation and β cell regeneration are among the suggested treatment strategies for type 1 diabetes. It has been shown that some antimicrobial peptides have the potential to increase insulin release and to… read more here.

Keywords: cell; insulin therapy; cell regeneration; treatment ... See more keywords

Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization

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recommendations! Published in 2020 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201910168

Abstract: Oral insulin therapy that targets the liver and further mimics glucose‐responsive secretion holds promise for correcting defects in glucose metabolism caused by peripheral delivery. This work describes the construction of polymersomes (Pep‐PMS), which are composed… read more here.

Keywords: pep pms; hepatic glucose; secretion; insulin ... See more keywords

Ursodeoxycholic Acid‐Decorated Zwitterionic Nanoparticles for Orally Liver‐Targeted Close‐Looped Insulin Delivery

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202302677

Abstract: Oral insulin therapies targeting the liver and further simulating close‐looped secretion face significant challenges due to multiple trans‐epithelial barriers. Herein, ursodeoxycholic acid (UDCA)‐decorated zwitterionic nanoparticles (NPs) (UC‐CMs@ins) are designed to overcome these barriers, target the… read more here.

Keywords: ursodeoxycholic acid; decorated zwitterionic; insulin; cms ins ... See more keywords

An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice

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recommendations! Published in 2023 at "Advanced Materials"

DOI: 10.1002/adma.202210392

Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.

Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords

Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202105619

Abstract: Abstract Rapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection therapy, so there… read more here.

Keywords: insulin release; rapid insulin; rapamycin; release ... See more keywords

Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and Tumorigenesis.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202206826

Abstract: The amino acid-stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation and function, but little is known about the effects of growth factors on… read more here.

Keywords: flcn phosphorylation; mediated mtorc1; mtorc1 activation; phosphorylation ... See more keywords