Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.035
Abstract: Mitochondria undergo dynamic changes to maintain function in eukaryotic cells. Insulin action in parallel regulates glucose homeostasis, but whether specific changes in mitochondrial dynamics alter insulin action and glucose homeostasis remains elusive. Here, we report… read more here.
Keywords: fission; dynamin related; insulin action; mitochondrial fission ... See more keywords
Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32354-w
Abstract: Increased lipid metabolism in muscle is associated with insulin resistance and therefore, many strategies have been employed to alter fatty acid metabolism and study the impact on insulin action. Metabolism of fatty acid requires activation… read more here.
Keywords: muscle; insulin action; acyl coa;
Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200173
Abstract: Cigarette smoking (CS) is known to reduce body weight and this often masks its real effect on insulin action. The present study tested the hypothesis that CS can divert lipid deposition to muscles to offset… read more here.
Keywords: weight gain; insulin action; muscle; gain ... See more keywords
Insulin action in the brain: Roles in energy and glucose homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12513
Abstract: A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates diverse aspects of energy balance and peripheral glucose homeostasis. This… read more here.
Keywords: insulin; glucose homeostasis; energy; insulin action ... See more keywords
Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12887
Abstract: Many overweight/obese subjects appear metabolically healthy with normal in vivo insulin sensitivity. Still, they have increased long‐term risk of developing type 2 diabetes. We hypothesized that adipose tissue dysfunction involving decreased insulin action in adipocytes… read more here.
Keywords: overweight obese; insulin action; healthy overweight; obese subjects ... See more keywords
Relationships of Insulin Action to Age, Gender, Body Mass Index, and Waist Circumference Present Diversely in Different Glycemic Statuses among Chinese Population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Research"
DOI: 10.1155/2018/1682959
Abstract: Introduction To study the influence of different glycemic statuses on the relationship of insulin action to age, gender, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) among Chinese population. Methods A total… read more here.
Keywords: glycemic statuses; age; insulin action; action age ... See more keywords
Skeletal muscle RUNX1 is related to insulin sensitivity through its effect on myogenic potential.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-21-0776
Abstract: OBJECTIVE Skeletal muscle is the major site of insulin action. There are limited data on the relationship between insulin action and skeletal muscle myogenic/regenerative potential. RUNX1 is a transcription factor which plays a role in… read more here.
Keywords: insulin action; muscle runx1; skeletal muscle; muscle ... See more keywords
Infant Mesenchymal Stem Cell Insulin Action is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0812
Abstract: Preclinical rodent and non-human primate models investigating maternal obesity have highlighted the importance of the intrauterine environment for development of insulin resistance in the offspring; however, it remains unclear if these findings can be translated… read more here.
Keywords: insulin action; free fatty; mesenchymal stem; obesity ... See more keywords
Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.708431
Abstract: Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue, skeletal muscle and liver, and these responses are significantly attenuated in insulin resistance leading to type 2 diabetes. Contrasting with insulin’s function, macroautophagy/autophagy… read more here.
Keywords: insulin; autophagy insulin; insulin action; insulin resistance ... See more keywords
Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.895118
Abstract: Under healthy conditions, the pancreas responds to a glucose challenge by releasing insulin. Insulin suppresses lipolysis in adipose tissue, thereby decreasing plasma glycerol concentration, and it regulates plasma glucose concentration through action in muscle and… read more here.
Keywords: insulin action; action; dynamics insulin; insulin ... See more keywords