Modulating Insulin Aggregation with Charge Variable Cholic Acid-Derived Polymers.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01107
Abstract: To understand the effect of cholic acid (CA)-based charge variable polymeric architectures on modulating the insulin aggregation process, herein, we have designed side-chain cholate-containing charge variable polymers. Three different types of copolymers from 2-(methacryloyloxy)ethyl cholate… read more here.
Keywords: aggregation; insulin aggregation; cholic acid; process ... See more keywords
Multi-Level High-Throughput Screening for Discovery of Ligands That Inhibit Insulin Aggregation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00219
Abstract: We have developed a multi-level virtual screening protocol to identify lead molecules from the FDA inactives database that can inhibit insulin aggregation. The method is based on the presence of structural and interaction specificity in… read more here.
Keywords: aggregation; aggregation prone; multi level; insulin aggregation ... See more keywords
Elucidation of the Effect of Phospholipid Charge on the Rate of Insulin Aggregation and Structure and Toxicity of Amyloid Fibrils
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00159
Abstract: The plasma membrane is a dynamic structure that separates the cell interior from the extracellular space. The fluidity and plasticity of the membrane determines a large number of physiologically important processes ranging from cell division… read more here.
Keywords: insulin aggregation; structure toxicity; charge; structure ... See more keywords