Mechanism of rutin mediated inhibition of insulin amyloid formation and protection of Neuro-2a cells from fibril-induced apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05393-8
Abstract: Many metabolic and neurodegenerative diseases are associated with protein misfolding and aggregation. Insulin a key hormone, under certain conditions aggregates and forms pathological amyloid fibrils. Several polyphenols have been studied extensively to elucidate their inhibitory… read more here.
Keywords: insulin; fibril induced; insulin amyloid; rutin ... See more keywords
Blended polar/nonpolar peptide conjugate interferes with human insulin amyloid-mediated cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104899
Abstract: Insulin, a peptide hormone and a key regulator of blood glucose level, is routinely administered to type-I diabetic patients to achieve the required glycemic control. Insulin aggregation and ensuing amyloidosis has been observed at repeated… read more here.
Keywords: insulin; peptide conjugate; insulin amyloid; amyloid mediated ... See more keywords
Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.09.132
Abstract: Amyloid protein aggregates are not only associated with neurodegenerative diseases and may also occur as unwanted by-products in protein-based therapeutics. Surfactants are often employed to stabilize protein formulations and reduce the risk of aggregation. However,… read more here.
Keywords: insulin; aggregation; morphology; insulin amyloid ... See more keywords
Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation
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DOI: 10.1038/s41598-020-64010-7
Abstract: Deposits of protein misfolding and/or aggregates are a pathological hallmark of amyloid-related diseases. For instance, insulin amyloid fibril deposits have been observed in patients with insulin-dependent diabetes mellitus after insulin administration. Here, we report on… read more here.
Keywords: insulin; amyloid; amyloid fibrils; insulin amyloid ... See more keywords