Basal Insulin Analogs versus Neutral Protamine Hagedorn for Type 2 Diabetics.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of perinatology"
DOI: 10.1055/s-0039-1694733
Abstract: OBJECTIVE To determine whether basal insulin analogs reduce the rate of composite neonatal morbidity compared with neutral protamine Hagedorn (NPH) in women with type 2 diabetes mellitus (T2DM). STUDY DESIGN This was a retrospective cohort… read more here.
Keywords: insulin analogs; neutral protamine; composite neonatal; neonatal morbidity ... See more keywords
Biosimilar insulin concepts
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DOI: 10.1111/1753-0407.13267
Abstract: Insulin use has dramatically increased over the past 30 years, in part because of the increasing realization of its role in the treatment of type 2 diabetes (T2D) (Figure 1A). Worldwide, the prevalence of type… read more here.
Keywords: insulin analogs; biosimilar insulin; insulin; reference product ... See more keywords
Clinical effects, cardiovascular and renal outcomes associated with rapid-acting insulin analogs among individuals with type 2 diabetes: a nation-wide observational cohort study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Diabetes and Endocrinology"
DOI: 10.1186/s40842-017-0043-2
Abstract: BackgroundRapid-acting insulin analogs (RAIs) have not been examined for long-term safety in randomized clinical trials. We performed a nationwide longitudinal cohort study among individuals with type 2 diabetes (T2DM) to address cardiovascular safety and mortality… read more here.
Keywords: individuals type; insulin analogs; among individuals; type diabetes ... See more keywords
Soluble insulin analogs combining rapid- and long-acting hypoglycemic properties – From an efficient E. coli expression system to a pharmaceutical formulation
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DOI: 10.1371/journal.pone.0172600
Abstract: The discovery of insulin led to a revolution in diabetes management. Since then, many improvements have been introduced to insulin preparations. The availability of molecular genetic techniques has enabled the creation of insulin analogs by… read more here.
Keywords: insulin; insulin analogs; soluble insulin; combining rapid ... See more keywords
Status and trends in the use of insulin analogs, insulin delivery systems and their association with glycemic control: comparison of the two consecutive recent cohorts of Japanese children and adolescents with type 1 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2018-0329
Abstract: Abstract Background Treatment for type 1 diabetes mellitus (T1DM) has greatly changed by the general use of insulin analogs and continuous subcutaneous insulin infusion (CSII). To investigate whether these advances have been translated into continued… read more here.
Keywords: children adolescents; japanese children; insulin analogs; glycemic control ... See more keywords
Cost-effectiveness of insulin analogs from the perspective of the Brazilian public health system
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902017000300178
Abstract: Human insulin is provided by the Brazilian Public Health System (BPHS) for the treatment of diabetes, however, legal proceedings to acquire insulin analogs have burdened the BPHS health system. The aim of this study was… read more here.
Keywords: insulin; insulin analogs; cost effectiveness; cost ... See more keywords
Using ultra-rapid insulin analogs in children and adolescents with type 1 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Endocrinology"
DOI: 10.22141/2224-0721.13.8.2017.119273
Abstract: Мета дослідження. Ретроспективний порівняльний аналіз використання аналогів інсуліну пролонгованої та ультракороткої дії і людських генно-інженерних інсулінів середньої і короткої дії у дітей і підлітків, хворих на цукровий діабет (ЦД) 1-го типу. Матеріали та методи. У… read more here.
Keywords: ultra rapid; using ultra; insulin analogs; analogs children ... See more keywords
Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
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DOI: 10.3389/fendo.2017.00167
Abstract: A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production, which is the main contributing factor to diabetic… read more here.
Keywords: insulin; selective insulin; insulin analogs; insulin receptor ... See more keywords