Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.04.006
Abstract: Due to the increasing prevalence of diabetes, finding therapeutic analogues for insulin has become an urgent issue. While many experimental studies have been performed towards this end, they have limited scope to examine all aspects… read more here.
Keywords: dynamics energetics; activity; computational study; insulin analogues ... See more keywords
Fast-Acting Insulin Aspart and the Need for New Mealtime Insulin Analogues in Adults With Type 1 and Type 2 Diabetes: A Canadian Perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2019.01.004
Abstract: Limiting postprandial glucose (PPG) excursions is an important aspect of overall glycemic control. Rapid-acting insulin analogues (RAIAs) aim to mimic the physiologic action of endogenous insulin observed in individuals without diabetes and prevent excessive PPG… read more here.
Keywords: insulin; insulin analogues; type diabetes; insulin aspart ... See more keywords
Utilizing ELISA‐plate based immunopurification and liquid chromatography‐tandem mass spectrometry for the urinary detection of short‐ and long acting human insulin analogues
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.02.024
Abstract: HighlightsQualitative measurement of human urinary insulin analogues is described.Ultrafiltration and immunoaffinity purification are utilized.LODs in the low pg/ml range are achieved using conventional HPLC system.Proof of principle is shown by the analysis of excretion samples.… read more here.
Keywords: insulin; detection; insulin analogues; liquid chromatography ... See more keywords
Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01388
Abstract: Insulin is a lifesaver for millions of diabetic patients. There is a need for new insulin analogues with more physiological profiles and analogues that will be thermally more stable than human insulin. Here, we describe… read more here.
Keywords: insulin; isoform; insulin analogues; insulin receptor ... See more keywords
Oligomerization of Pharmaceutically Relevant Insulin Analogues for Varying Concentration and Salinity Revealed by Small-Angle X-ray Scattering.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00164
Abstract: Two different insulin analogues, insulin degludec and lithocholyl insulin, were studied by small-angle X-ray scattering with respect to their self-assembly and interactions in solution at different concentrations of insulin and salt, NaCl. Very different behavior… read more here.
Keywords: insulin; small angle; insulin analogues; angle ray ... See more keywords
Biosimilars and Novel Insulins.
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000001079
Abstract: BACKGROUND Insulin therapy is the mainstay of treatment for type 1 diabetes and may be necessary in type 2 diabetes. Current insulin analogues present a more physiological profile, are effective, and with less risk of… read more here.
Keywords: biosimilar insulins; insulin; insulin aspart; faster aspart ... See more keywords
Are newer insulin analogues better for people with Type 1 diabetes?
Sign Up to like & getrecommendations! Published in 2018 at "Diabetic Medicine"
DOI: 10.1111/dme.13891
Abstract: Achieving optimal blood glucose control in Type 1 diabetes is a delicate balance between ensuring tight glycaemic control and achieving this without the expense of hypoglycaemia and weight gain, two major factors impacting quality of… read more here.
Keywords: insulin; newer insulin; control; people type ... See more keywords
Corrigendum to “Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe: Findings and Implications”
Sign Up to like & getrecommendations! Published in 2023 at "BioMed Research International"
DOI: 10.1155/2023/9757348
Abstract: [This corrects the article DOI: 10.1155/2021/9996193.]. read more here.
Keywords: trend long; insulin analogues; utilisation trend; corrigendum utilisation ... See more keywords
The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2021.671961
Abstract: Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. The risk of complications are enhanced by poor glycaemic control including hypoglycaemia.… read more here.
Keywords: insulin; use; long acting; insulin glargine ... See more keywords
Review: Rapid-acting analogues do not differ from regular human insulin for mortality or HbA1c in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Internal Medicine"
DOI: 10.7326/acpj201904160-039
Abstract: Question In patients with type 2 diabetes mellitus, what are the efficacy and safety of rapid-acting insulin analogues compared with regular human insulin (RHI)? Review scope Included studies compared rapid-acting insulin analogues (insulin lispro, insulin… read more here.
Keywords: insulin; type diabetes; rapid acting; mortality ... See more keywords