ERp29 as a regulator of Insulin biosynthesis
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DOI: 10.1371/journal.pone.0233502
Abstract: The environment within the Endoplasmic Reticulum (ER) influences Insulin biogenesis. In particular, ER stress may contribute to the development of Type 2 Diabetes (T2D) and Cystic Fibrosis Related Diabetes (CFRD), where evidence of impaired Insulin… read more here.
Keywords: erp29; insulin; whole cell; insulin biosynthesis ... See more keywords
The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival
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DOI: 10.2337/db18-0073
Abstract: Stress-related changes in β-cell mRNA levels result from a balance between gene transcription and mRNA decay. The regulation of RNA decay pathways has not been investigated in pancreatic β-cells. We found that no-go and nonsense-mediated… read more here.
Keywords: insulin; decay; insulin biosynthesis; human islets ... See more keywords
1783-P: Translocon-Associated Protein Alpha (TRAPα) Is Required for Insulin Biosynthesis in ß Cells
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DOI: 10.2337/db19-1783-p
Abstract: The discovery of missense mutations in the signal peptide of preproinsulin that causes congenital diabetes highlights the critical role of ER translocation in insulin biosynthesis. However, the mechanisms that govern these early events in insulin… read more here.
Keywords: protein alpha; insulin biosynthesis; trap; translocon associated ... See more keywords