The effect of wasting and stunting during severe acute malnutrition in infancy on insulin sensitivity and insulin clearance in adult life
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174422000034
Abstract: Abstract Adults who had non-edematous severe acute malnutrition (SAM) during infancy (i.e., marasmus) have worse glucose tolerance and beta-cell function than survivors of edematous SAM (i.e., kwashiorkor). We hypothesized that wasting and/or stunting in SAM… read more here.
Keywords: insulin clearance; malnutrition; infancy; wasting stunting ... See more keywords
The sodium–glucose cotransporter 2 inhibitor ipragliflozin improves liver function and insulin resistance in Japanese patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05704-y
Abstract: Sodium–glucose cotransporter 2 inhibitor (SGLT2i) treatment is a therapeutic approach for type 2 diabetes mellitus (T2DM). Some reports have shown that SGLT2i treatment improves insulin resistance; however, few studies have evaluated insulin resistance by the… read more here.
Keywords: insulin resistance; insulin; treatment; hepatic insulin ... See more keywords
Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-0098
Abstract: There is wide variance among individuals in the fraction of insulin cleared by the liver (20% to 80%). Hepatic insulin clearance is 67% lower in African Americans than European Americans. Clearance is also lower in… read more here.
Keywords: insulin; insulin clearance; hepatic insulin; type diabetes ... See more keywords
1330-P: Ethnic Differences in Insulin Clearance: Relationship with Admixture Scores, Diet, and Physical Activity
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1330-p
Abstract: Recent studies showed that hepatic insulin clearance is lower in African Americans (AA) than European Americans (EA). The aim of this work is to elucidate the possible genetic/epigenetic versus lifestyle causes. The frequently-sampled intravenous glucose… read more here.
Keywords: hepatic insulin; admixture; insulin clearance; physical activity ... See more keywords
Comment on Piccinini and Bergman The Measurement of Insulin Clearance. Diabetes Care 2020;43:2296–2302
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes Care"
DOI: 10.2337/dc20-2444
Abstract: We found interesting the review by Piccinini and Bergman (1) about the methods for assessing insulin clearance. However, some issues deserve comment. The authors claim that single-compartment description of C-peptide kinetics may provide limited accuracy.… read more here.
Keywords: insulin; model; single compartment; insulin clearance ... See more keywords
Insulin Clearance in Obesity and Type 2 Diabetes
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DOI: 10.3390/ijms23020596
Abstract: Plasma insulin clearance is an important determinant of plasma insulin concentration. In this review, we provide an overview of the factors that regulate insulin removal from plasma and discuss the interrelationships among plasma insulin clearance,… read more here.
Keywords: insulin clearance; obesity; type diabetes; insulin ... See more keywords
The Physiology of Insulin Clearance
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DOI: 10.3390/ijms23031826
Abstract: In the 1950’s, Dr. I. Arthur Mirsky first recognized the possible importance of insulin degradation changes to the pathogenesis of type 2 diabetes. While this mechanism was ignored for decades, insulin degradation is now being… read more here.
Keywords: clearance; insulin clearance; importance; diabetes risk ... See more keywords
Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions
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DOI: 10.3390/ijms23147667
Abstract: Background: The liver has the capacity to regulate glucose metabolism by altering the insulin clearance rate (ICR). The decreased fasting insulin concentrations and enhanced prandial hyperinsulinemia after Roux-en-Y gastric-bypass (GB) surgery and sleeve gastrectomy (SG)… read more here.
Keywords: insulin clearance; gastric bypass; sleeve gastrectomy; insulin ... See more keywords
Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021729
Abstract: Sleeve gastrectomy (SG) successfully recovers metabolic homeostasis in obese humans and rodents while also resulting in the normalization of insulin sensitivity and insulinemia. Reduced insulin levels have been attributed to lower insulin secretion and increased… read more here.
Keywords: insulin clearance; obese mice; sleeve gastrectomy; insulin ... See more keywords
Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
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DOI: 10.3390/metabo11070420
Abstract: Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously… read more here.
Keywords: insulin; insulin clearance; secretion; insulin secretion ... See more keywords