Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201822
Abstract: Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate… read more here.
Keywords: cell; oxidized alginate; insulin delivery; glucose responsive ... See more keywords
An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210392
Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.
Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords
Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid.
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202400520
Abstract: Oral insulin delivery systems are currently being explored as the best alternative to subcutaneous injections, aiming to overcome gastrointestinal barriers and achieve efficient oral insulin delivery. This study presents a microemulsion delivery system that utilizes… read more here.
Keywords: insulin; insulin delivery; chitosan sodium; delivery ... See more keywords
Glucose‐Responsive Modified Poly(Propylene Imine) Dendrimer for Self‐Regulated Insulin Delivery
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular Materials and Engineering"
DOI: 10.1002/mame.202500265
Abstract: Diabetes is characterized by inadequate insulin secretion and elevated blood glucose levels, and patients require continuous insulin infusion and continuous glucose monitoring. Self‐regulating insulin delivery systems, which use glucose‐sensitive materials for dynamic and automatic insulin… read more here.
Keywords: insulin; insulin delivery; propylene imine; self ... See more keywords
The role of automated insulin delivery technology in diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Diabetologia"
DOI: 10.1007/s00125-024-06165-w
Abstract: The role of automated insulin delivery systems in diabetes is expanding. Hybrid closed-loop systems are being used in routine clinical practice for treating people with type 1 diabetes. Encouragingly, real-world data reflects the performance and… read more here.
Keywords: technology; role automated; insulin delivery; loop systems ... See more keywords
Numerical simulation of a glucose sensitive composite membrane closed-loop insulin delivery system
Sign Up to like & getrecommendations! Published in 2017 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-017-1803-1
Abstract: Closed-loop insulin delivery system works on pH modulation by gluconic acid production from glucose, which in turn allows regulation of insulin release across membrane. Typically, the concentration variation of gluconic acid can be numerically modeled… read more here.
Keywords: insulin; system; loop insulin; insulin delivery ... See more keywords
Stimuli-Responsive Insulin Delivery Devices.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02918-5
Abstract: The development of new diabetes treatment strategies has garnered much interest given that conventional management therapies for type 1 diabetes fail to provide optimal glycemic control while creating a high burden of self-care to patients.… read more here.
Keywords: responsive insulin; delivery; delivery devices; stimuli responsive ... See more keywords
Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9419-3
Abstract: For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system… read more here.
Keywords: insulin; prandial insulin; hydrogel; delivery ... See more keywords
Timing of Insulin with Meals in the Hospital: a Systems Improvement Approach
Sign Up to like & getrecommendations! Published in 2019 at "Current Diabetes Reports"
DOI: 10.1007/s11892-019-1232-4
Abstract: Coordination of glucose monitoring, mealtimes, and insulin delivery in the hospital is complex, involving interactions between multiple key agents and overlapping workflows. The purpose of this review is to evaluate the scope of the problem… read more here.
Keywords: insulin; hospital systems; insulin meals; timing insulin ... See more keywords
Insulin Delivery Technology for Treatment of Infants with Neonatal Diabetes Mellitus: A Systematic Review
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes Therapy"
DOI: 10.1007/s13300-024-01653-z
Abstract: Neonatal diabetes mellitus is a rare disorder of glucose metabolism with onset within the first 6 months of life. The initial treatment is based on insulin infusion. The technologies for diabetes treatment can be very… read more here.
Keywords: treatment; insulin delivery; diabetes mellitus; infants neonatal ... See more keywords
Experience of People with Diabetes Treated with Insulin Delivery Systems in France: A Comparative Analysis of Multiple Daily Injections, Tubeless Pumps, Tubed Pumps, and Hybrid Closed Loops
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes Therapy"
DOI: 10.1007/s13300-024-01682-8
Abstract: While people with diabetes (PWD)’s experiences with their insulin delivery systems (IDS) are frequently reported in clinical trials, few real-world data exist on the subject. This study aimed to assess the real-world experience and satisfaction… read more here.
Keywords: tubeless; tubed pumps; tubeless pumps; insulin delivery ... See more keywords