Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201822
Abstract: Self‐regulated insulin delivery that mimics native pancreas function has been a long‐term goal for diabetes therapies. Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate… read more here.
Keywords: cell; oxidized alginate; insulin delivery; glucose responsive ... See more keywords
An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210392
Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.
Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords
Numerical simulation of a glucose sensitive composite membrane closed-loop insulin delivery system
Sign Up to like & getrecommendations! Published in 2017 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-017-1803-1
Abstract: Closed-loop insulin delivery system works on pH modulation by gluconic acid production from glucose, which in turn allows regulation of insulin release across membrane. Typically, the concentration variation of gluconic acid can be numerically modeled… read more here.
Keywords: insulin; system; loop insulin; insulin delivery ... See more keywords
Stimuli-Responsive Insulin Delivery Devices.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02918-5
Abstract: The development of new diabetes treatment strategies has garnered much interest given that conventional management therapies for type 1 diabetes fail to provide optimal glycemic control while creating a high burden of self-care to patients.… read more here.
Keywords: responsive insulin; delivery; delivery devices; stimuli responsive ... See more keywords
Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9419-3
Abstract: For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system… read more here.
Keywords: insulin; prandial insulin; hydrogel; delivery ... See more keywords
Timing of Insulin with Meals in the Hospital: a Systems Improvement Approach
Sign Up to like & getrecommendations! Published in 2019 at "Current Diabetes Reports"
DOI: 10.1007/s11892-019-1232-4
Abstract: Coordination of glucose monitoring, mealtimes, and insulin delivery in the hospital is complex, involving interactions between multiple key agents and overlapping workflows. The purpose of this review is to evaluate the scope of the problem… read more here.
Keywords: insulin; hospital systems; insulin meals; timing insulin ... See more keywords
CREATE (Community deRivEd AutomaTEd insulin delivery) trial. Randomised parallel arm open label clinical trial comparing automated insulin delivery using a mobile controller (AnyDANA-loop) with an open-source algorithm with sensor augmented pump therapy in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes and Metabolic Disorders"
DOI: 10.1007/s40200-020-00547-8
Abstract: Background Commercialised automated insulin delivery (AID) systems have demonstrated improved outcomes in type 1 diabetes (T1D), however, they have limited capacity for algorithm individualisation, and can be prohibitively expensive if an individual is without access… read more here.
Keywords: insulin; trial; automated insulin; insulin delivery ... See more keywords
Advances in transdermal insulin delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2018.12.006
Abstract: Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the… read more here.
Keywords: insulin; delivery; advances transdermal; insulin delivery ... See more keywords
Microgel encapsulated nanoparticles for glucose-responsive insulin delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120458
Abstract: An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial.… read more here.
Keywords: insulin; responsive insulin; glucose responsive; insulin delivery ... See more keywords
Role of Glucagon in Automated Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2019.10.008
Abstract: Treatment of type 1 diabetes with exogenous insulin often results in unpredictable daily glucose variability and hypoglycemia, which can be dangerous. Automated insulin delivery systems can improve glucose control while reducing burden for people with… read more here.
Keywords: role glucagon; glucagon; delivery; automated insulin ... See more keywords
An overview of oral insulin delivery strategies (OIDS).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.144
Abstract: Despite tremendous efforts, the world continues its fight against the common chronic disease-diabetes. Diabetes is caused by elevated glucose levels in the blood, which can lead to several complications like glaucoma, cataract, kidney failure, diabetic… read more here.
Keywords: route; delivery strategies; insulin; oral insulin ... See more keywords