Comparative analysis of buffalo (Bubalus bubalis) non-transgenic and transgenic embryos containing human insulin gene, produced by SCNT.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.06.004
Abstract: Somatic cell nuclear transfer (SCNT), using transgenic donor cells, is a highly efficient method for producing transgenic embryos. We compared the developmental competence, quality and gene expression of transgenic embryos produced by Hand-made cloning from… read more here.
Keywords: embryos; non transgenic; transgenic embryos; gene ... See more keywords
Low risk for diabetic complications in type 1 diabetes patients carrying a protective insulin gene variant
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DOI: 10.1371/journal.pone.0280872
Abstract: Type 1 diabetes patients carrying a ‘protective’ insulin gene (INS) variant present a disease endotype with reduced insulin antibody titers, preserved beta cell function and improved glycemic control. We tested whether this protective INS variant… read more here.
Keywords: insulin gene; carrying protective; type diabetes; patients carrying ... See more keywords
PIASy is a SUMOylation-independent negative regulator of the insulin transactivator MafA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-19-0172
Abstract: Insulin plays a central role in glucose homeostasis and is produced exclusively by pancreatic islet β-cells. Insulin gene transcription is regulated by a set of β-cell-enriched transcription factors that bind to cis-regulatory elements within the… read more here.
Keywords: insulin; promoter; piasy; insulin gene ... See more keywords