Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart
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DOI: 10.1128/mcb.00163-22
Abstract: Insulin and insulin-like growth factor 1 (IGF1) signaling is transduced by insulin receptor substrate 1 (IRS1) and IRS2. To elucidate physiological and redundant roles of insulin and IGF1 signaling in adult hearts, we generated mice… read more here.
Keywords: igf1 signaling; insulin igf1; factor; heart ... See more keywords
The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
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DOI: 10.3390/biom11040531
Abstract: Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively. Evidence accumulated in recent years indicates that, in addition to their typical cell-surface localization pattern and… read more here.
Keywords: insulin; insr igf1r; insulin igf1; igf1r ... See more keywords