Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci88477
Abstract: The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy in a streptozotocin-induced rat model of DKA. Leptin infusion reduced rates of lipolysis, hepatic… read more here.
Keywords: acute insulin; insulin independent; corticosterone; ketoacidosis ... See more keywords
Actions of Apolipoprotein A-IV on Insulin-Independent Glucose Control and Activation of Akt in Mouse Liver
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1777-p
Abstract: Insulin resistance is a risk factor for type 2 diabetes, fatty liver and metabolic syndrome. We reported previously that apolipoprotein A-IV (ApoA4) increased insulin secretion, insulin sensitivity and improved glucose uptake in adipocytes by PI3K-Akt… read more here.
Keywords: insulin; insulin independent; apoa4; liver ... See more keywords
Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-independent Glucose Uptake via Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0035
Abstract: Caveolin-1 (cav1) is an important structural and signaling component of plasma membrane invaginations called caveolae and is abundant in adipocytes. As previously reported, adipocyte-specific ablation of the cav1 gene (ad-cav1KO mouse) does not result in… read more here.
Keywords: extracellular vesicles; independent glucose; insulin independent; mice ... See more keywords
Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.680153
Abstract: A large contribution to glucose elimination from the circulation is achieved by insulin-independent processes. We have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) increase this process and,… read more here.
Keywords: insulin independent; glucose; glucose disposal; mice ... See more keywords