Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.10.029
Abstract: Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) increase insulin signaling in skeletal muscle. In the current study, we investigated the effect of eicosapentaenoic acid (EPA) on insulin-induced mammalian target of rapamycin (mTOR) phosphorylation in myotubes.… read more here.
Keywords: mtor phosphorylation; insulin; induced mtor; insulin induced ... See more keywords
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101210
Abstract: Objective Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compensatory metabolic programmes that… read more here.
Keywords: nash progression; suppression insulin; insig1; progression ... See more keywords
Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104745
Abstract: AIM AND OBJECTIVE Insulin-induced moderate or severe hypoglycemia (MH or SH) impairs cognition and SH causes neuronal death. On the contrary, alternate day fasting (ADF) protects the brain during excitotoxic stress and improves cognitive function.… read more here.
Keywords: insulin; nitrotyrosine expression; metabolism; brain ... See more keywords
Antagonistic Insulin Derivative Suppresses Insulin-Induced Hypoglycemia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00280
Abstract: Insulin derivatives provide new functions that are distinctive from native insulin. We investigated insulin modifications on the C-terminal A chain with insulin receptor (IR) peptide binders and presented a full and potent IR antagonist. We… read more here.
Keywords: insulin induced; insulin derivative; induced hypoglycemia; suppresses insulin ... See more keywords
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08585-4
Abstract: Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig.… read more here.
Keywords: insig; induced gene; ampk dependent; gene ... See more keywords
Acute effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Physiology"
DOI: 10.1113/ep090584
Abstract: What is the central question of this study? What are the effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity in vivo and how do carotid body chemoreceptor stimulation‐mediated cardiorespiratory responses in beagle… read more here.
Keywords: insulin induced; body chemoreceptor; carotid body; induced hypoglycaemia ... See more keywords
Role of pregnancy on insulin-induced vasorelaxation: the influence of angiotensin II receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2021-0057
Abstract: Pregnancy is characterized by insulin resistance that is associated with increased angiotensin II (AngII) and insulin levels. Therefore, pregnancy may change insulin-induced vasodilation through changes in AngII receptors. Insulin-induced vasorelaxation was evaluated in phenylephrine-precontracted aortic… read more here.
Keywords: insulin; pregnancy; induced vasorelaxation; role pregnancy ... See more keywords
Role of preeclampsia on insulin-induced vasorelaxation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735209
Abstract: The objective of this project was to evaluate whether PE alters the vascular response to insulin. The physiological insulin resistance characteristic of pregnancy is increased in preeclamptic (PE) conditions. With the hypothesis that PE diminishes… read more here.
Keywords: insulin induced; abdominal aorta; physiology; thoracic abdominal ... See more keywords
Insulin-induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/9169296
Abstract: Background Lipohypertrophy (LH) of subcutaneous tissue is an insulin-induced complication occurring in patients with diabetes. We aimed to define the prevalence of LH and identify its risk factors in type 1 diabetes (T1DM) patients treated… read more here.
Keywords: insulin induced; t1dm patients; lipohypertrophy; risk factors ... See more keywords
Short-term fasting lowers glucagon levels under euglycemic and hypoglycemic conditions in healthy humans.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.169789
Abstract: Fasting is associated with increased susceptibility to hypoglycemia in people with type 1 diabetes, thereby making it a significant health risk. To date, the relationship between fasting and insulin-induced hypoglycemia has not been well characterized,… read more here.
Keywords: insulin induced; induced hypoglycemia; glucagon levels; hypoglycemia ... See more keywords
Evaluating the significance of hypoglycemia in promoting insulin induced hypertension by using a glucose clamp model
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Mathematics"
DOI: 10.14419/ijm.v5i1.6813
Abstract: Background: Hypoglycemia unawareness is a detrimental risk factor in diabetic patients leading to serious complications if left untreated. Previous studies from our group determined that recurrent insulin induced hypoglycemia (RIIH) promotes hypertension. Objective: We hypothesize… read more here.
Keywords: insulin; hypoglycemia; model; hypertension ... See more keywords