Similar Pharmacokinetics and Pharmacodynamics of Biosimilar SAR342434 Insulin Lispro and Japan‐Approved Humalog Insulin Lispro in Healthy Japanese Subjects
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DOI: 10.1002/cpdd.1068
Abstract: This phase 1 study compared the pharmacokinetic (PK) and glucose pharmacodynamic (PD) characteristics of biosimilar SAR342434 insulin lispro and Japan‐reference Humalog insulin lispro. This was a randomized, double‐blind, 2‐period, crossover study. Thirty‐six healthy Japanese male… read more here.
Keywords: time; humalog insulin; concentration; insulin lispro ... See more keywords
Comparison of insulin lispro mix 25 with insulin lispro mix 50 as an insulin starter in Asian patients with type 2 diabetes: a phase 4, open‐label, randomized trial (CLASSIFY study)
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DOI: 10.1002/dmrr.2816
Abstract: Lispro Mix 25% insulin lispro/75% insulin lispro protamine (LM25) and Lispro Mix 50% insulin lispro/50% insulin lispro protamine (LM50) were compared as starter insulins in East Asian patients with type 2 diabetes. read more here.
Keywords: insulin; asian patients; insulin lispro; mix insulin ... See more keywords
Modeling Pharmacokinetic Profiles of Insulin Regimens to Enhance Understanding of Subcutaneous Insulin Regimens
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DOI: 10.1002/jcph.899
Abstract: Insulin pharmacokinetics following subcutaneous administration were modeled, simulated, and displayed through an interactive and user‐friendly interface to illustrate the time course of administered insulins frequently prescribed, providing a simple tool for clinicians through a straightforward… read more here.
Keywords: insulin; time; insulin lispro; model ... See more keywords
Ultra‐rapid BioChaperone Lispro improves postprandial blood glucose excursions vs insulin lispro in a 14‐day crossover treatment study in people with type 1 diabetes
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DOI: 10.1111/dom.13442
Abstract: To investigate the safety and efficacy of BioChaperone Lispo (BCLIS), an ultra‐rapid formulation of insulin lispro (LIS) in people with type 1 diabetes. read more here.
Keywords: ultra rapid; biochaperone; people type; insulin lispro ... See more keywords
Insulin lispro 25/75 and insulin lispro 50/50 as starter insulin in Japanese patients with type 2 diabetes: subanalysis of the CLASSIFY randomized trial.
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DOI: 10.1507/endocrj.ej17-0020
Abstract: In Japan, premixed insulins are commonly used as starter insulin for type 2 diabetes. This subpopulation analysis assessed the efficacy and safety of twice-daily LM25 (25% insulin lispro/75% insulin lispro protamine) and LM50 (50% insulin… read more here.
Keywords: lispro insulin; insulin; trial; starter insulin ... See more keywords
Efficacy and Safety of Intramuscular Insulin Lispro vs. Continuous Intravenous Regular Insulin for the Treatment of Dogs With Diabetic Ketoacidosis
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DOI: 10.3389/fvets.2020.559008
Abstract: The use of rapid-acting insulin analogs as routes of administration other than IV has never been described for the treatment of dogs with diabetic ketoacidosis (DKA). This study aims to compare the efficacy and safety… read more here.
Keywords: insulin; ketoacidosis; treatment; group ... See more keywords