LAUSR

Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment.

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0 Published in 2020 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2019.115506

Abstract: In this study, insulin-loaded nanoparticles (NPs) were prepared via self-gelation method using chitosan and aqueous soluble snail mucin as natural polymers. Herein, mucins were ionically interacted with chitosan at different concentrations to obtained insulin-loaded NPs,… read more here.

Keywords: insulin; delivery; insulin loaded; mucin chitosan ... See more keywords

Biocompatibility and safety of insulin-loaded chitosan nanoparticles/ PLGA-PEG-PLGA hydrogel (ICNPH) delivered by subconjunctival injection in rats

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0 Published in 2019 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2018.12.032

Abstract: Abstract Ocular drug delivery, specifically protein drug delivery to the posterior segment of the eye, remains a challenge. The purpose of this study was to prepare a new double-controlled drug release system (with insulin as… read more here.

Keywords: insulin loaded; drug; insulin; icnph ... See more keywords

Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro

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0 Published in 2020 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2020.101738

Abstract: Abstract A successful oral protein nanocarrier needs to exhibit the following characteristics: stability in the gastrointestinal (GI) tract, drug release at specific site, overcoming high mucus turnover, mucoadhesive properties and enhanced epithelial absorption. The purpose… read more here.

Keywords: insulin; loaded chitosan; insulin loaded; formulation ... See more keywords

Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats

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0 Published in 2021 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2021.102601

Abstract: Abstract Diabetes skin infection is a very common disorder in hyperglycemic patients. This study evaluated the prospective of developing a topical gel formulation of Aloe vera with insulin-loaded nanoemulsion and evaluates its potential for wound… read more here.

Keywords: insulin loaded; aloe vera; wound healing; vera ... See more keywords

Formulation development, in vitro and in vivo evaluation of chitosan engineered nanoparticles for ocular delivery of insulin

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0 Published in 2020 at "RSC Advances"

DOI: 10.1039/d0ra07640f

Abstract: Insulin-dependent diabetic patients have to count on the administration of painful and discomforting insulin injections. However, inadequate insulin absorption and the risk of insulin level escalation in the blood are some disadvantages associated with insulin… read more here.

Keywords: insulin; vivo; insulin loaded; development vitro ... See more keywords