Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.08.013
Abstract: The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β cells has recently been questioned as small amounts of C-peptide are detectable in patients with long-standing disease. We analyzed protein… read more here.
Keywords: insulin; type diabetes; proinsulin; expression ... See more keywords
A 12‐week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.05.011
Abstract: ABSTRACT The discovery of gut sweet taste receptors has led to speculations that non‐nutritive sweeteners, including sucralose, may affect glucose control. A double‐blind, parallel, randomized clinical trial, reported here and previously submitted to regulatory agencies,… read more here.
Keywords: clinical trial; week; insulin peptide; glucose insulin ... See more keywords
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac196
Abstract: Abstract Context Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of… read more here.
Keywords: somatic mutation; proinsulin processing; proinsulin levels; insulin peptide ... See more keywords
Current Status of Serum Insulin and C-Peptide Measurement in Clinical Laboratories: Experience from 94 Laboratories in China.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of laboratory medicine"
DOI: 10.3343/alm.2022.42.4.428
Abstract: Background Accurate measurements of serum insulin and C-peptide are needed for the therapy and classification of diabetes. This study investigated the status of serum insulin and C-peptide measurements in China by analyzing the results of… read more here.
Keywords: insulin; measurement; serum insulin; insulin peptide ... See more keywords
The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose, Insulin and C-peptide Kinetics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.868364
Abstract: Background The MTNR1B gene encodes a receptor for melatonin, a hormone regulating biorhythms. Disruptions in biorhythms contribute to the development of type 2 diabetes mellitus (T2DM). Genetic studies suggest that variability in the MTNR1B gene… read more here.
Keywords: glucose insulin; polymorphism; insulin peptide; insulin ... See more keywords
Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8050108
Abstract: Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels… read more here.
Keywords: four hour; insulin; hyperinsulinaemia; correlation ... See more keywords