Co‐microencapsulation of human umbilical cord‐derived mesenchymal stem and pancreatic islet‐derived insulin producing cells in experimental type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3372
Abstract: Post‐partum umbilical cord Wharton Jelly‐derived adult mesenchymal stem cells (hUCMS) hold anti‐inflammatory and immunosuppressive properties. Human pancreatic islet‐derived progenitor cells (hIDC) may de‐differentiate, and subsequently re‐differentiate into insulin producing cells. The two cell types share… read more here.
Keywords: pancreatic islet; umbilical cord; producing cells; islet derived ... See more keywords
GATA factors in pancreas development and disease
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2170
Abstract: There is an urgent need for the development of novel therapeutics options for diabetic patients given the high prevalence of diabetes worldwide and that, currently, there is no cure for this disease. The transplantation of… read more here.
Keywords: producing cells; pancreas development; disease; factors pancreas ... See more keywords
Generation of Functional Insulin-Producing Cells from Mouse Embryonic Stem Cells Through Protein Transduction of Transcription Factors.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0943-9_7
Abstract: In this chapter, we describe a simple and unique method for the differentiation of mouse embryonic stem cells into insulin-producing cells. In addition to cytokines and growth factors, key transcription factors for pancreatic development are… read more here.
Keywords: transcription factors; producing cells; mouse embryonic; embryonic stem ... See more keywords
Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04870-z
Abstract: A reduction in the number of functional β-cells is the central pathological event in diabetes. Liver and ventral pancreas differentiates simultaneously in the same general domain of cells within embryonic endoderm. In addition, the precursor… read more here.
Keywords: vector free; hepatic stem; producing cells; stem ... See more keywords
Transplantation of Macroencapsulated Insulin-Producing Cells
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DOI: 10.1007/s11892-018-1028-y
Abstract: Purpose of ReviewThere is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This review aims to summarize recent advances, to highlight remaining challenges, and to provide recommendations for the… read more here.
Keywords: insulin; macroencapsulated insulin; producing cells; beta ... See more keywords
In vitro differentiation induction of embryonal carcinoma stem cells into insulin-producing cells by Cichorium intybus L. leaf extract.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112214
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Medicinal herb Cichorium intybus L. (chicory) has been used traditionally for the treatment of various diseases, including diabetes. One of the promising therapeutic options to treat diabetes is replacing the degenerative pancreatic β… read more here.
Keywords: cichorium intybus; producing cells; leaf extract; differentiation ... See more keywords
iPSCs-laden GDF8-grafted aldehyde hyaluronic acid-polyacrylamide inverted colloidal crystal constructs with controlled release of CHIR99021 and retinoic acid to generate insulin-producing cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of The Taiwan Institute of Chemical Engineers"
DOI: 10.1016/j.jtice.2020.11.002
Abstract: Abstract Recent advances in attempting maturation of pancreatic β cells derived from induced pluripotent stem cells (iPSCs) have initiated a gateway to developing innovated materials and protocols for artificial pancreas implantation in diabetic management. In… read more here.
Keywords: producing cells; chir99021; colloidal crystal; inverted colloidal ... See more keywords
Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
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DOI: 10.1038/s41467-019-12472-3
Abstract: Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show that viable and functional islet organoids can… read more here.
Keywords: epithelial cells; amniotic epithelial; treat; islet ... See more keywords
Direct differentiation of bone marrow mononucleated cells into insulin producing cells using pancreatic β-cell-derived components
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DOI: 10.1038/s41598-019-41823-9
Abstract: Transplantation of stem cell-derived insulin producing cells (IPCs) has been proposed as an alternative to islet transplantation for the treatment of diabetes mellitus. However, current IPC differentiation protocols are focused on generating functional cells from… read more here.
Keywords: producing cells; direct differentiation; cell derived; differentiation ... See more keywords
Role of miR-128/216a Regulating Isl1 Expression during Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Insulin-Producing Cells
Sign Up to like & getrecommendations! Published in 2023 at "Wuhan University Journal of Natural Sciences"
DOI: 10.1051/wujns/2023282177
Abstract: Islet-1 (Isl1), a LIM homeodomain protein, is expressed in the embryonic pancreatic epithelium. As a key transcription factor, Isl1 can not only regulate insulin gene expression in normal glucose condition but also maintain β-cell function… read more here.
Keywords: isl1 expression; expression; insulin producing; differentiation ... See more keywords
Direct Reprogramming of Mice Skin Fibroblasts into Insulin-Producing Cells In Vitro.
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DOI: 10.1089/cell.2021.0047
Abstract: Transdifferentiation means mature cell conversion into other mature cells. Ethical issues, epigenetic failure, or teratoma development are found in cellular reprogramming strategies. Thus, new methods are needed. This study aimed to develop a new novel… read more here.
Keywords: producing cells; method; mice; insulin producing ... See more keywords