Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.02.002
Abstract: Despite substantial advances in the research exploring the pathogenesis of Type 1 Diabetes (T1D), the pathophysiological mechanisms involved remain unknown. We hypothesized in this study that interferon alpha (IFNα) participates in the early stages of… read more here.
Keywords: insulin production; stress; beta cells; beta ... See more keywords
Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dietary supplements"
DOI: 10.1080/19390211.2021.1914267
Abstract: Olives (Olea europaea) have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating… read more here.
Keywords: production circulating; leaf powder; olive leaf; group ... See more keywords
Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract
Sign Up to like & getrecommendations! Published in 2019 at "Pancreas"
DOI: 10.1097/mpa.0000000000001320
Abstract: Objectives We have investigated the efficacy of mono- and combined therapy with green tea extract (GTE) in mobilizing redox iron, scavenging reactive oxygen species (ROS), and improving insulin production in iron-loaded pancreatic cells. Methods Rat… read more here.
Keywords: green tea; insulin production; insulin; tea extract ... See more keywords
A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)
Sign Up to like & getrecommendations! Published in 2020 at "AMB Express"
DOI: 10.1186/s13568-020-00969-w
Abstract: Insulin has captured researchers’ attention worldwide. There is a rapid global rise in the number of diabetic patients, which increases the demand for insulin. Current methods of insulin production are expensive and time-consuming. A PCR-based… read more here.
Keywords: novel efficient; insulin; protein; insulin production ... See more keywords
&bgr;-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03120
Abstract: Mammalian metabolism has evolved to adapt to changes in nutrient status. Insulin, the key anabolic hormone, facilitates intracellular storage of nutrient fuels and plays a pivotal role in the transition away from catabolism upon refeeding.… read more here.
Keywords: insulin; male rats; capacity; insulin production ... See more keywords
MiR-221/222 inhibit insulin production of pancreatic β-cells in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/endocr/bqz027
Abstract: MicroRNAs are essential for the regulation of development, proliferation and functions of pancreatic β-cells. The conserved miR-221/222 cluster is an important regulator in multiple cellular processes. Here we investigated the functional role of miR-221/222 in… read more here.
Keywords: mir 221; proliferation; 221 222; insulin production ... See more keywords