Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01250
Abstract: Autoimmune diseases are believed to be highly dependent on loss of immune tolerance to self-antigens. Currently, no treatments have been successful clinically in inducing autoantigen-specific tolerance, including efforts to utilize antigen-specific immunotherapy (ASIT) to selectively… read more here.
Keywords: valency; antigen; insulin reactive; soluble antigen ... See more keywords
Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.961209
Abstract: Seropositivity for autoantibodies against multiple islet antigens is associated with development of autoimmune type 1 diabetes (T1D), suggesting a role for B cells in disease. The importance of B cells in T1D is indicated by… read more here.
Keywords: insulin reactive; high affinity; affinity; type diabetes ... See more keywords