Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28359
Abstract: The contribution of proximal tubules (PT) to albumin uptake is now well recognized, however, its regulation is understudied area. There are reports suggesting that insulin resistance is associated with the development of albuminuria in nondiabetic… read more here.
Keywords: insulin receptor; insulin; excretion; albumin excretion ... See more keywords
Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4606-2
Abstract: Aims/hypothesisBi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have been shown to activate two mutant receptors,… read more here.
Keywords: insulin; insulin receptor; insr; insulin receptoropathy ... See more keywords
The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications
Sign Up to like & getrecommendations! Published in 2019 at "Gastric Cancer"
DOI: 10.1007/s10120-019-00964-6
Abstract: BackgroundMetabolic reprogramming in gastric cancer (GC) involves not only an alteration of glucose metabolism, but also of insulin receptor (IR) expression. We investigated if (1) GCs express the IR in cancer cells (CC-IR) and vasculature… read more here.
Keywords: status; her2 status; gastric cancer; insulin receptor ... See more keywords
Insulin and the insulin receptor collaborate to promote human gastric cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gastric Cancer"
DOI: 10.1007/s10120-021-01236-y
Abstract: Gastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom have elevated circulating insulin concentrations. High plasma insulin concentrations may promote, and increase mortality from, gastric… read more here.
Keywords: insulin; gastric adenocarcinoma; insulin receptor; cancer ... See more keywords
New classification and diagnostic criteria for insulin resistance syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Diabetology International"
DOI: 10.1007/s13340-022-00570-5
Abstract: This report of a working group established by the Japan Diabetes Society proposes a new classification and diagnostic criteria for insulin resistance syndrome. Insulin resistance syndrome is defined as a condition characterized by severe attenuation… read more here.
Keywords: insulin receptor; resistance syndrome; insulin resistance; insulin ... See more keywords
First report of insulin receptor in thysanoptera and its expression variation with development of western flower thrips, Frankliniella occidentalis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Asia-Pacific Entomology"
DOI: 10.1016/j.aspen.2021.09.007
Abstract: Abstract Insulin signaling is required for insect development. Insulin-like peptides and their signalings have been extensively assessed in various insects. However, little is known about them in Thysanoptera. This study identified the first insulin receptor… read more here.
Keywords: insulin; thysanoptera; insulin receptor; expression ... See more keywords
Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.02.030
Abstract: Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid signaling via cytoplasmic kinases. However, mechanisms mediating long-term effects… read more here.
Keywords: insulin; genome wide; promoters genome; insulin receptor ... See more keywords
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.11.013
Abstract: Increased hepatic glucose production (HGP) contributes to hyperglycemia in type 2 diabetes. Hormonal regulation of this process is primarily, but not exclusively, mediated by the AKT-FoxO1 pathway. Here, we show that cAMP and dexamethasone regulate… read more here.
Keywords: glucose production; insulin; tox4; insulin receptor ... See more keywords
Role of surface-exposed charged basic amino acids (Lys, Arg) and guanidination in insulin on the interaction and stability of insulin-insulin receptor complex
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107501
Abstract: Naturally occurring proteins are emerging as novel therapeutics in the protein-based biopharmaceutical industry for the treatment of diabetes and obesity. However, proteins are not suitable for oral delivery due to short half-life, reduced physical and… read more here.
Keywords: insulin; insulin receptor; interaction; lys arg ... See more keywords
Clinical characteristics in two patients with partial lipodystrophy and Type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene.
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2019.04.034
Abstract: AIMS The present report aimed to clarify the clinical characteristics in a girl at the age of 12 and her mother with partial lipodystrophy and Type A insulin resistance syndrome. METHODS We examined fat distribution… read more here.
Keywords: insulin; insulin receptor; lipodystrophy; insulin resistance ... See more keywords
Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.12.005
Abstract: A growing body of evidence supports the involvement of disturbances in the brain insulin pathway in the pathogenesis of depression. On the other hand, data concerning the impact of antidepressant drug therapy on brain insulin… read more here.
Keywords: insulin receptor; insulin; receptor phosphorylation; antidepressant drug ... See more keywords