Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models
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DOI: 10.1007/s00125-018-4606-2
Abstract: Aims/hypothesisBi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have been shown to activate two mutant receptors,… read more here.
Keywords: insulin; insulin receptor; insr; insulin receptoropathy ... See more keywords