Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00904
Abstract: The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin-regulated aminopeptidase (IRAP); however, reports on clinically relevant inhibitors are limited. Here we… read more here.
Keywords: hydroxy amino; insulin regulated; regulated aminopeptidase; amino acid ... See more keywords
Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations
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DOI: 10.1111/acel.13810
Abstract: The immune system plays a central role in many processes of age‐related disorders and it remains unclear if the innate immune system may play roles in shaping extreme longevity. By an integrated analysis with multiple… read more here.
Keywords: longevity; enhanced insulin; insulin regulated; immune system ... See more keywords
Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle
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DOI: 10.2337/db21-0855
Abstract: Insulin-stimulated muscle glucose uptake is a key process in glycemic control. This process depends on the redistribution of glucose transporters to the surface membrane, a process that involves regulatory proteins such as TBC1D1 and TBC1D4.… read more here.
Keywords: muscle; insulin regulated; insulin stimulated; skeletal muscle ... See more keywords
From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.590855
Abstract: It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related… read more here.
Keywords: small peptidemimetics; regulated aminopeptidase; irap; insulin regulated ... See more keywords