An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210392
Abstract: Glucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles… read more here.
Keywords: insulin release; glucose responsive; insulin delivery; responsive insulin ... See more keywords
Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105619
Abstract: Abstract Rapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection therapy, so there… read more here.
Keywords: insulin release; rapid insulin; rapamycin; release ... See more keywords
The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05552-x
Abstract: The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand Māori) populations. This study investigates… read more here.
Keywords: insulin; rs373863828; insulin release; ancestry ... See more keywords
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.05.010
Abstract: Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control. However, the precise mechanisms underlying nutrient sensing in POMC neurons remain incompletely understood. We show that mitochondrial dynamics… read more here.
Keywords: dynamics mediated; pomc neurons; glucose sensing; insulin release ... See more keywords
Regulated basal and bolus insulin release from glucose-responsive core-shell microspheres based on concanavalin A-sugar affinity.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.030
Abstract: Individual insulin therapy considering the heterogeneity of insulin resistance between patients may bring more benefits than conventional therapy. Therefore, in glucose-responsive insulin delivery systems, more attention should be paid on further regulation of insulin release… read more here.
Keywords: shell; insulin; insulin release; core shell ... See more keywords
Concanavalin A-sugar affinity based system: Binding interactions, principle of glucose-responsiveness, and modulated insulin release for diabetes care.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.11.261
Abstract: The glucose-responsive behavior of the Con A-sugar affinity based hydrogels, microgels, films and nanoparticles has been widely investigated in the application of drug delivery and biosensors. However, the principle or mechanism of such systems is… read more here.
Keywords: insulin; insulin release; sugar affinity; release ... See more keywords
Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of β cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of environmental sciences"
DOI: 10.1016/j.jes.2021.07.004
Abstract: Per- and polyfluoroalkyl substances (PFAS) are found to have multiple adverse outcomes on human health. Recently, epidemiological and toxicological studies showed that exposure to PFAS had adverse impacts on pancreas and showed association with insulin… read more here.
Keywords: cell viability; insulin; pfos; insulin release ... See more keywords
Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.11.007
Abstract: HighlightszfGIP stimulates insulin release from clonal &bgr;‐cells and mouse islets.zfGIP administration improves glucose tolerance in mice.Insulin release from BRIN‐BD11 cells is attenuated by a GLP‐1R antagonist.zfGIP stimulates cAMP production in CHL cells transfected with GLP‐1R.zfGIP… read more here.
Keywords: bgr; insulin release; zfgip; receptor ... See more keywords
Regulatory Mechanisms of SNAP-25-Associated Insulin Release Revealed by Live-Cell Confocal and Single-Molecule Localization Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02677
Abstract: Impaired insulin release is the key feature of type 2 diabetes. Insulin secretion, mainly mediated by SNARE proteins, is closely related to the blood glucose level. However, the mechanism underlying how glucose controls SNARE proteins… read more here.
Keywords: insulin release; localization; live cell; cell confocal ... See more keywords
H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.6b06892
Abstract: A self-regulated "smart" insulin administration system would be highly desirable for diabetes management. Here, a glucose-responsive insulin delivery device, which integrates H2O2-responsive polymeric vesicles (PVs) with a transcutaneous microneedle-array patch was prepared to achieve a… read more here.
Keywords: insulin; insulin delivery; insulin release; h2o2 responsive ... See more keywords
Magnetic particles for triggering insulin release in INS-1E cells subjected to a rotating magnetic field.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr02009b
Abstract: Diabetes is a major global health threat. Both academics and industry are striving to develop effective treatments for this disease. In this work, we present a new approach to induce insulin release from β-islet pancreatic… read more here.
Keywords: magnetic field; field; magnetic particles; insulin release ... See more keywords