Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.18811
Abstract: Key Points Question Which gut microbial taxa are associated with the development of type 2 diabetes? Findings In this cross-sectional study of 2166 participants in 2 large population-based studies, lower microbiome Shannon index and richness… read more here.
Keywords: gut microbial; type diabetes; resistance type; insulin resistance ... See more keywords
Analysis of Insulin Resistance Among Children and Adolescents in Slovenia With Hypercholesterolemia After Treatment With Statins
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.31097
Abstract: This cohort study assesses the association between short-term treatment with rosuvastatin therapy and changes in insulin resistance markers among children and adolescents in Slovenia who have hypercholesterolemia. read more here.
Keywords: among children; insulin resistance; slovenia hypercholesterolemia; adolescents slovenia ... See more keywords
Which Patients With Ischemic Stroke and Insulin Resistance May Benefit From Pioglitazone Hydrochloride?
Sign Up to like & getrecommendations! Published in 2017 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2017.2142
Abstract: The Insulin Resistance Intervention After Stroke (IRIS) trial has reported that treating insulin resistance with the peroxisome proliferator–activated receptor γ agonist pioglitazone hydrochloride reduced recurrent stroke or myocardial infarction (MI) by about onefourth compared with… read more here.
Keywords: neurology; risk; pioglitazone; risk stroke ... See more keywords
Assessment of Insulin Resistance Among Drug-Naive Patients With First-Episode Schizophrenia in the Context of Hormonal Stress Axis Activation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2017.1983
Abstract: Before the introduction of antipsychotics, links between schizophrenia and abnormal glucose metabolism levels were found in the late 1800s as an increased prevalence of diabetes in families with a history of “insanity.”1 Furthermore, it is… read more here.
Keywords: among drug; schizophrenia; first episode; insulin resistance ... See more keywords
Association of Insulin Resistance With Depression Severity and Remission Status: Defining a Metabolic Endophenotype of Depression.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3669
Abstract: This study investigates whether insulin resistance was positively associated with the presence, severity, or chronicity of major depression. read more here.
Keywords: depression; severity; association insulin; insulin resistance ... See more keywords
Egr‐1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia‐induced insulin resistance in the liver in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13537
Abstract: During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long‐term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown.… read more here.
Keywords: resistance liver; hyperinsulinemia; liver; type diabetes ... See more keywords
Hepatic Phospholipid Remodeling Modulates Insulin Sensitivity and Systemic Metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300416
Abstract: The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin action in the liver is a major driver of selective insulin resistance, in which insulin fails to suppress glucose production but… read more here.
Keywords: insulin resistance; metabolism; insulin sensitivity; insulin ... See more keywords
Inflammation and insulin resistance: New targets encourage new thinking
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700036
Abstract: Galectin‐3 and LTB4 are pro‐inflammatory molecules recently shown to directly cause insulin resistance in mouse and human cells. They are highly expressed in the obese state, and can be targeted both genetically and pharmacologically to… read more here.
Keywords: insulin; insulin resistance; inflammation insulin; new targets ... See more keywords
Prediagnostic markers of insulin resistance and prostate cancer risk and death: A pooled study.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6004
Abstract: BACKGROUND Insulin resistance has been shown to be related to a higher risk of several cancers, but the association with prostate cancer (PCa) has been inconsistent. METHODS We investigated prediagnostic markers of insulin resistance in… read more here.
Keywords: insulin resistance; pca; death; risk ... See more keywords
Insulin resistance influences the impact of hypertension on left ventricular diastolic dysfunction in a community sample
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cardiology"
DOI: 10.1002/clc.23145
Abstract: Although obesity‐associated metabolic abnormalities (insulin resistance‐IR) may not play as marked a role in determining left ventricular (LV) diastolic dysfunction (DD) as hypertension, the impact of combinations of these risk factors on DD is unknown. read more here.
Keywords: ventricular diastolic; diastolic dysfunction; left ventricular; insulin resistance ... See more keywords
Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the Women’s Health Initiative
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33002
Abstract: Insulin resistance is associated with higher all‐cause and cancer‐specific mortality in postmenopausal women. However, to the authors' knowledge, information regarding insulin resistance and breast cancer mortality risk is limited. Therefore, the authors examined associations between… read more here.
Keywords: cancer; resistance breast; mortality; insulin resistance ... See more keywords