Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.18811
Abstract: Key Points Question Which gut microbial taxa are associated with the development of type 2 diabetes? Findings In this cross-sectional study of 2166 participants in 2 large population-based studies, lower microbiome Shannon index and richness… read more here.
Keywords: gut microbial; type diabetes; resistance type; insulin resistance ... See more keywords
Analysis of Insulin Resistance Among Children and Adolescents in Slovenia With Hypercholesterolemia After Treatment With Statins
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.31097
Abstract: This cohort study assesses the association between short-term treatment with rosuvastatin therapy and changes in insulin resistance markers among children and adolescents in Slovenia who have hypercholesterolemia. read more here.
Keywords: among children; insulin resistance; slovenia hypercholesterolemia; adolescents slovenia ... See more keywords
Childhood Exposure to Air Pollution, Body Mass Index Trajectories, and Insulin Resistance Among Young Adults
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.6431
Abstract: Key Points Question Do body mass index (BMI) growth trajectories mediate the association of air pollution exposure with insulin resistance? Findings In this cohort study of 282 participants tracked from pregnancy to 24 years of… read more here.
Keywords: air pollution; exposure; insulin resistance;
Which Patients With Ischemic Stroke and Insulin Resistance May Benefit From Pioglitazone Hydrochloride?
Sign Up to like & getrecommendations! Published in 2017 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2017.2142
Abstract: The Insulin Resistance Intervention After Stroke (IRIS) trial has reported that treating insulin resistance with the peroxisome proliferator–activated receptor γ agonist pioglitazone hydrochloride reduced recurrent stroke or myocardial infarction (MI) by about onefourth compared with… read more here.
Keywords: neurology; risk; pioglitazone; risk stroke ... See more keywords
Assessment of Insulin Resistance Among Drug-Naive Patients With First-Episode Schizophrenia in the Context of Hormonal Stress Axis Activation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2017.1983
Abstract: Before the introduction of antipsychotics, links between schizophrenia and abnormal glucose metabolism levels were found in the late 1800s as an increased prevalence of diabetes in families with a history of “insanity.”1 Furthermore, it is… read more here.
Keywords: among drug; schizophrenia; first episode; insulin resistance ... See more keywords
Association of Insulin Resistance With Depression Severity and Remission Status: Defining a Metabolic Endophenotype of Depression.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.3669
Abstract: This study investigates whether insulin resistance was positively associated with the presence, severity, or chronicity of major depression. read more here.
Keywords: depression; severity; association insulin; insulin resistance ... See more keywords
Egr‐1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia‐induced insulin resistance in the liver in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13537
Abstract: During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long‐term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown.… read more here.
Keywords: resistance liver; hyperinsulinemia; liver; type diabetes ... See more keywords
Hepatic Phospholipid Remodeling Modulates Insulin Sensitivity and Systemic Metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300416
Abstract: The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin action in the liver is a major driver of selective insulin resistance, in which insulin fails to suppress glucose production but… read more here.
Keywords: insulin resistance; metabolism; insulin sensitivity; insulin ... See more keywords
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202508991
Abstract: Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, the molecular mechanism by which mitochondrial protein acetylation influences hepatic IR remains incompletely elucidated. To investigate this biology, GCN5L1 liver knockout… read more here.
Keywords: insulin resistance; calcium; grp75; acetylation ... See more keywords
Association Between Relative Leg Length and Insulin Resistance in Rural, Urban and Rural–Urban Migrant Populations of Peru
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Human Biology"
DOI: 10.1002/ajhb.70105
Abstract: To determine the association between relative leg length and insulin resistance according to rural, urban, and rural–urban migrant groups. read more here.
Keywords: rural urban; relative leg; insulin resistance; association relative ... See more keywords
Inflammation and insulin resistance: New targets encourage new thinking
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700036
Abstract: Galectin‐3 and LTB4 are pro‐inflammatory molecules recently shown to directly cause insulin resistance in mouse and human cells. They are highly expressed in the obese state, and can be targeted both genetically and pharmacologically to… read more here.
Keywords: insulin; insulin resistance; inflammation insulin; new targets ... See more keywords