Metformin accelerate wound healing by Akt phosphorylation of gingival fibroblast in insulin-resistant prediabetes mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of periodontology"
DOI: 10.1002/jper.21-0362
Abstract: BACKGROUND This study aimed to investigate the effects of metformin on gingival wound healing in insulin-resistant prediabetes. METHODS C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for 10 weeks; half of the… read more here.
Keywords: gingival; wound healing; akt phosphorylation; insulin resistant ... See more keywords
Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin-resistant canine model.
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23771
Abstract: OBJECTIVE Sodium-glucose cotransporter 2 inhibitors (SGLT2i) promote urinary glucose excretion, induce weight loss, and reduce fat accumulation. The effects of the SGLT2i dapagliflozin (DAPA) on subcutaneous (SC) and visceral (VIS) adipose tissue function remain unclear.… read more here.
Keywords: insulin resistant; adipose tissue; resistant canine; dapa ... See more keywords
Resistant starch from black rice, Oryza sativa L. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7675
Abstract: It has recently been reported that black rice (BR) extract has anti‐obesity, anti‐diabetic, and anti‐osteoporosis effects. It has been shown to reduce obese‐related kidney dysfunction in animal models. This study aimed to investigate the effect… read more here.
Keywords: insulin resistant; renal inflammation; resistant rats; injury ... See more keywords
The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-020-02012-y
Abstract: Aluminum is well recognized as a nephrotoxic agent. Its hazardous effects arise from the high risk of daily exposure. The consumption of fructose also represents a critical health issue that might negatively impact different organs,… read more here.
Keywords: tlr4 signaling; resistant rats; signaling pathway; glycyrrhizic acid ... See more keywords
Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients
Sign Up to like & getrecommendations! Published in 2020 at "Acta Diabetologica"
DOI: 10.1007/s00592-020-01567-9
Abstract: Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently… read more here.
Keywords: microbiota; perception lipids; orosensory perception; perception ... See more keywords
Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03590-z
Abstract: Azoramide is identified as a new compound with the dual properties for the improvement of ER-folding capacity in various cells as well as for the treatment of T2DM. Although the effect of azoramide in glucose-homeostasis… read more here.
Keywords: insulin; h9c2 cells; treatment; insulin resistant ... See more keywords
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Insulin Sensitivity in Insulin Resistant Human Adipocytes
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2323-4
Abstract: Insulin resistance is an essential characteristic of type 2 diabetes mellitus (T2DM), which can be induced by glucotoxicity and adipose chronic inflammation. Mesenchymal stem cells (MSCs) and their exosomes were reported to ameliorate T2DM and… read more here.
Keywords: insulin; exosomes derived; insulin resistant; stem cells ... See more keywords
Phenotypic characterization of patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-019-00777-4
Abstract: Type 2 diabetes mellitus harbors heterogeneity. This study describes the phenotypic subgroups based on anthropometric and biochemical characteristics. This was a cross-sectional study involving 96 patients with early type 2 diabetes conducted from July 2017… read more here.
Keywords: insulin; beta cell; type diabetes; diabetes mellitus ... See more keywords
Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104061
Abstract: Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective… read more here.
Keywords: c2c12 cells; resistant c2c12; poncirin; c2c12 ... See more keywords
Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, Improves Trabecular Bone Mineral Density and Microstructure in Obese, Insulin-Resistant, Pre-diabetic Rats.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2018.01.006
Abstract: OBJECTIVE Obese insulin resistance and type 2 diabetes mellitus profoundly impair bone mechanical properties and bone quality. However, because several antidiabetes drugs, especially thiazolidinediones, further aggravate bone loss in individuals with diabetes, diabetic osteopathy should… read more here.
Keywords: insulin; bone mineral; obese insulin; bone ... See more keywords
Possible Role of MicroRNA in Equine Insulin Resistance: A Pilot Study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Equine Veterinary Science"
DOI: 10.1016/j.jevs.2017.10.024
Abstract: &NA; MicroRNAs (miRNAs) are a class of small endogenous single‐stranded noncoding RNA molecules that have important roles in several biological processes. Research in human and laboratory animals has shown that miRNAs can regulate genes associated… read more here.
Keywords: insulin sensitive; insulin; study; insulin resistant ... See more keywords