Generation of glucose sensitive insulin-secreting cells from human induced pluripotent stem cells on optimized polyethersulfone (PES) hybrid nanofibrous scaffold.
Sign Up to like & getrecommendations! Published in 2022 at "Artificial organs"
DOI: 10.1111/aor.14431
Abstract: BACKGROUND In the realm of diabetes treatment, various strategies have been tried, including islet transplantation and common drug therapies, but the limitations of these procedures and lack of responsive to the high number of patients… read more here.
Keywords: secreting cells; insulin secreting; group; stem ... See more keywords
SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin secreting cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260049
Abstract: Glucose sensing in pancreatic beta-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for down-stream effectors of glucose dependent signal transduction in INS-1E insulinoma cells, we… read more here.
Keywords: stress; secreting cells; slc25a46; insulin secreting ... See more keywords