Insulin secretion and action affect glucose variability in the early stages of glucose intolerance
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3531
Abstract: Since it is unknown whether glucose variability (GV) is increased and whether this is related to worsening of insulin secretion and action in prediabetes, we have assessed insulin secretion and sensitivity, and daily GV in… read more here.
Keywords: secretion action; secretion; insulin secretion; glucose variability ... See more keywords
Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22488
Abstract: Insulinomas originate from pancreatic β cells and it is the most widely known tumor. Indomethacin is a nonsteroidal anti‐inflammatory drug, which is used for blocking the production of some natural substances that cause inflammation and… read more here.
Keywords: secretion; insulin secretion; apoptotic cell; indomethacin ... See more keywords
Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.23970
Abstract: BACKGROUND Due to the loss of responsiveness to insulin, diabetes mellitus (DM) patients develop increased platelet reactivity and reduced response to antiplatelet agents. Nevertheless, the relationship between the single-nucleotide polymorphisms (SNP) of the signal pathway… read more here.
Keywords: gene; clopidogrel resistance; insulin secretion; clopidogrel ... See more keywords
Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.1965
Abstract: The main goal of this study was to investigate pancreatic islet function with mesenchymal stem cells (MSCs) in a ligand‐functionalized poly(ethylene glycol) (PEG) hydrogel for the treatment of type 1 diabetes (T1D). Rat bone marrow‐derived… read more here.
Keywords: insulin secretion; incorporation; poly ethylene; stem cells ... See more keywords
Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H2O2 induced INS‐1 cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23636
Abstract: Oxidative stress is an important factor that causes pancreatic β‐cell dysfunction leading to the development and aggravation of diabetes. Swietenine (Stn) and swietenolide (Std) were isolated from the fruits of Swietenia macrophylla King and had… read more here.
Keywords: stn std; ins cells; apoptosis; insulin secretion ... See more keywords
Insulin releasing effect of some pure compounds from Moringa oleifera on mice islets
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2157-1
Abstract: The anti-diabetic activity of extracts, fractions and compounds of Moringa oleifera have been reported; however, several constituents from this well known medicinal plant are not yet screened for bio-perspecting role for diabetes. Current studies demonstrated… read more here.
Keywords: compounds moringa; insulin; oleifera; moringa oleifera ... See more keywords
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4743-7
Abstract: Aims/hypothesisPancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds… read more here.
Keywords: insulin secretion; beta cell; mice; beta ... See more keywords
Dimethyl sulfoxide acutely enhances regulated insulin secretion in the MIN6-K8 mouse insulinoma cell line.
Sign Up to like & getrecommendations! Published in 2021 at "Histochemistry and cell biology"
DOI: 10.1007/s00418-021-01984-z
Abstract: Diabetes mellitus is a metabolic disorder projected to afflict 700 million people globally by 2045. Fundamental to the progression of diabetes is an insufficient supply of insulin to meet metabolic demand. The MIN6-K8 cell line… read more here.
Keywords: insulin secretion; secretion; cell line; min6 ... See more keywords
Pathophysiological characteristics in patients with latent autoimmune diabetes in adults using clamp tests: evidence of a continuous disease spectrum of diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01387-6
Abstract: This study aimed to assess islet insulin secretion and insulin resistance in Chinese patients with latent autoimmune diabetes in adults (LADA). Twelve patients with LADA, 10 with type 1 diabetes mellitus (T1DM), 10 with type… read more here.
Keywords: patients latent; insulin; insulin secretion; autoimmune diabetes ... See more keywords
Liraglutide targets the gut microbiota and the intestinal immune system to regulate insulin secretion
Sign Up to like & getrecommendations! Published in 2021 at "Acta Diabetologica"
DOI: 10.1007/s00592-020-01657-8
Abstract: Liraglutide controls type 2 diabetes (T2D) and inflammation. Gut microbiota regulates the immune system and causes at least in part type 2 diabetes. We here evaluated whether liraglutide regulates T2D through both gut microbiota and… read more here.
Keywords: gut; insulin secretion; immune system; intestinal immune ... See more keywords
Combination Immunotherapy for Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Current Diabetes Reports"
DOI: 10.1007/s11892-017-0878-z
Abstract: Purpose of ReviewType 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell… read more here.
Keywords: combination immunotherapy; cell; insulin secretion; immunotherapy ... See more keywords