Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107665118
Abstract: Significance The failure of β cells to secrete sufficient amounts of insulin is a key feature of diabetes mellitus. Each β cell secretes only a small amount of insulin upon stimulation in a highly regulated… read more here.
Keywords: insulin; vivo; insulin secretory; model ... See more keywords
Relationships of the early insulin secretory response and oral disposition index with gastric emptying in subjects with normal glucose tolerance
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DOI: 10.14814/phy2.13122
Abstract: The oral disposition index, the product of the early insulin secretory response during an oral glucose tolerance test and insulin sensitivity, is used widely for both the prediction of, and evaluation of the response to… read more here.
Keywords: insulin; gastric emptying; disposition index; insulin secretory ... See more keywords
Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0056
Abstract: Objective Diabetes is a frequent comorbidity in cystic fibrosis (CF), related to multiple unfavorable outcomes. During the progression of β-cell dysfunction to diabetes, insulin deficiency could possibly reduce the anabolic support to grow even in… read more here.
Keywords: insulin secretory; secretion; adult height; insulin ... See more keywords
1384-P: Changes in OGTT-Based Measures of Insulin Secretory Response across Pregnancy
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DOI: 10.2337/db20-1384-p
Abstract: Background: We previously showed that insulin response to an IV glucose load increases in early pregnancy, independent of changes in insulin sensitivity. It is unknown whether oral glucose tolerance test (OGTT)-based measures of insulin secretory… read more here.
Keywords: based measures; pregnancy; response; measures insulin ... See more keywords
Glucagon Stimulation Test and Insulin Secretory Capacity in Clinical Assessment of Incretin-Based Therapy for Diabetes.
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DOI: 10.2337/db24-0518
Abstract: Evaluation of insulin secretory capacity is essential to understand the pathophysiological condition of individuals with diabetes and to assess the efficacy of drugs used in treatment of the disease. The 1 mg intravenous glucagon stimulation… read more here.
Keywords: insulin secretory; secretory capacity; insulin; glucagon stimulation ... See more keywords
1217-P: Insulin Sensitivity and Insulin Secretion Differentially Affect Birthweight and Postpartum Glucose
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DOI: 10.2337/db24-1217-p
Abstract: Background: Insulin deficiency and insulin resistance are two fundamental mechanisms that lead to hyperglycemia. Despite variation in the underlying physiology, individuals with hyperglycemia in pregnancy are treated similarly. Methods: Pregnant women with diabetes risk factors… read more here.
Keywords: insulin; none; postpartum; insulin sensitivity ... See more keywords