Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107665118
Abstract: Significance The failure of β cells to secrete sufficient amounts of insulin is a key feature of diabetes mellitus. Each β cell secretes only a small amount of insulin upon stimulation in a highly regulated… read more here.
Keywords: insulin; vivo; insulin secretory; model ... See more keywords
Relationships of the early insulin secretory response and oral disposition index with gastric emptying in subjects with normal glucose tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13122
Abstract: The oral disposition index, the product of the early insulin secretory response during an oral glucose tolerance test and insulin sensitivity, is used widely for both the prediction of, and evaluation of the response to… read more here.
Keywords: insulin; gastric emptying; disposition index; insulin secretory ... See more keywords
Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0056
Abstract: Objective Diabetes is a frequent comorbidity in cystic fibrosis (CF), related to multiple unfavorable outcomes. During the progression of β-cell dysfunction to diabetes, insulin deficiency could possibly reduce the anabolic support to grow even in… read more here.
Keywords: insulin secretory; secretion; adult height; insulin ... See more keywords
1384-P: Changes in OGTT-Based Measures of Insulin Secretory Response across Pregnancy
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DOI: 10.2337/db20-1384-p
Abstract: Background: We previously showed that insulin response to an IV glucose load increases in early pregnancy, independent of changes in insulin sensitivity. It is unknown whether oral glucose tolerance test (OGTT)-based measures of insulin secretory… read more here.
Keywords: based measures; pregnancy; response; measures insulin ... See more keywords