Network pharmacology integrated molecular dynamics reveals the bioactive compounds and potential targets of Tinospora crispa Linn. as insulin sensitizer
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DOI: 10.1371/journal.pone.0251837
Abstract: Insulin resistance is a metabolic disorder characterized by the decreased response to insulin in muscle, liver, and adipose cells. This condition remains a complex phenomenon that involves several genetic defects and environmental stresses. In the… read more here.
Keywords: insulin sensitizer; pharmacology; molecular dynamics; tinospora crispa ... See more keywords
Identification and Characterization of a Novel Insulin Sensitizer to Treat Diabetes and Nonalcoholic Steatohepatitis
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DOI: 10.2337/db18-237-lb
Abstract: Thiazolidinediones (TZDs) enhance insulin sensitivity and have efficacy for treating nonalcoholic steatohepatitis (NASH). However, the use of TZDs, like rosiglitazone and pioglitazone, has been curtailed by significant side effects mediated via the peroxisome proliferator-activated receptor… read more here.
Keywords: insulin; msdc 5514; insulin sensitizer; nonalcoholic steatohepatitis ... See more keywords
1786-P: The New Insulin Sensitizer MSDC-0602K Synergizes with the GLP-1 Receptor Agonist Liraglutide
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DOI: 10.2337/db20-1786-p
Abstract: First generation insulin sensitizers improve both hyperglycemia and hyperinsulinemia and can preserve beta cell mass and function. GLP-1 receptor agonists work by augmenting glucose-stimulated insulin secretion. Our objective was to assess potential additive effects of… read more here.
Keywords: insulin; insulin sensitizer; treatment; new insulin ... See more keywords