Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3‐L1 preadipocytes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13516
Abstract: Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and… read more here.
Keywords: 3t3 preadipocytes; insulin signaling; receptor; gpr50 ... See more keywords
Brain insulin signaling, Alzheimer's disease pathology, and cognitive function.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of neurology"
DOI: 10.1002/ana.25826
Abstract: OBJECTIVE To examine associations of molecular markers of brain insulin signaling with Alzheimer's disease (AD) and cognition, among older persons with or without diabetes. METHODS This clinical-pathologic study was derived from a community-based cohort study,… read more here.
Keywords: brain insulin; pathology; cognitive function; brain ... See more keywords
Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26398
Abstract: Long‐term use of methamphetamine (MA) causes a broad range of cognitive deficits. Recently, it has been reported insulin signaling and mitochondrial biogenesis are involved in cognitive processes. This study aimed to examine whether MA induces… read more here.
Keywords: insulin; cognitive deficits; signaling impairment; insulin treatment ... See more keywords
Exercise increases Rho‐kinase activity and insulin signaling in skeletal muscle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26278
Abstract: The effects of physical exercise on insulin signaling and glycemic homeostasis are not yet fully understood. Recent findings elucidated the positive role of Rho‐kinase (Rock) in increasing the glucose uptake through insulin receptor substrate‐1 (IRS1)… read more here.
Keywords: insulin; skeletal muscle; rock; exercise ... See more keywords
A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30779
Abstract: Today, growing evidence indicates that patients with type 2 diabetes (T2D) are at a higher risk of developing Alzheimer's disease (AD). Indeed, AD as one of the main causes of dementia in people aged more… read more here.
Keywords: signaling pathway; alzheimer disease; noncoding rnas; type diabetes ... See more keywords
IPMK modulates hepatic glucose production and insulin signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30827
Abstract: Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphosphate multikinase… read more here.
Keywords: ipmk; hepatic glucose; insulin signaling; glucose production ... See more keywords
Analytical comparison of absolute quantification strategies to investigate the Insulin signaling pathway in fat cells.
Sign Up to like & getrecommendations! Published in 2021 at "Proteomics"
DOI: 10.1002/pmic.202100136
Abstract: So far, mass spectrometry based targeted proteomics is the most sensitive approach to answer and address specific biological questions in an accurate and quantitative fashion. However, the data analysis design used for such quantification varies… read more here.
Keywords: quantification; analytical comparison; insulin signaling; insulin ... See more keywords
Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea.
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DOI: 10.1002/ps.7268
Abstract: BACKGROUND The insulin signaling pathway is closely related to metabolism, growth, reproductive capacity, and lifespan of insects. However, the physiological function of the insulin signaling pathway is little known in Hyphantria cunea. RESULTS Five insulin… read more here.
Keywords: signaling pathway; cunea; molecular targets; hyphantria cunea ... See more keywords
Microcystin‐LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22856
Abstract: Microcystin‐LR (MC‐LR) is a widely produced monocyclic heptapeptides in eutrophication waterbodies. MC‐LR can induce various toxic effects in different cells. Our previous studies have found that MC‐LR exposure can disrupt insulin signaling pathway in human… read more here.
Keywords: c2c12 mice; muscle; muscle cells; signaling pathway ... See more keywords
Excess glutamine does not alter myotube metabolism or insulin sensitivity
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DOI: 10.1007/s00726-022-03131-x
Abstract: Glutamine is an amino acid previously linked with improved skeletal muscle metabolism and insulin signaling, however, past observations often use cell culture models with only supraphysiological concentrations. Additionally, past reports have yet to simultaneously investigate… read more here.
Keywords: glutamine; metabolism insulin; insulin signaling; insulin ... See more keywords
3-Deoxyglucosone interferes with insulin signaling and attenuates insulin action on glucose-induced GLP-1 secretion in the enteroendocrine L cell line STC-1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04926-0
Abstract: Maintenance of glucose homeostasis is reciprocally regulated by insulin and glucagon-like peptide-1 (GLP-1). We previously reported that GLP-1 secretion in response to an oral glucose load was impaired following an administration of 3-deoxyglucosone (3DG), an independent… read more here.
Keywords: insulin; stc; induced glp; glp secretion ... See more keywords