Expression of Concern: Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4358-4
Abstract: In line with guidelines issued by the Committee on Publication Ethics (COPE), the journal informed the corresponding author, Mario Saad, of this concern. Dr Saad has confirmed that different membranes could indeed have been used… read more here.
Keywords: concern selective; insulin signalling; selective impairment; expression concern ... See more keywords
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.01.044
Abstract: ABSTRACT Alzheimer's disease (AD) constitutes a major socioeconomic challenge due to its disabling features and the rise in prevalence (especially among (peri)menopausal women and type 2 diabetes patients). The precise etiopathogenesis of AD remains poorly… read more here.
Keywords: insulin signalling; insulin; brain insulin; metabolism ... See more keywords
An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Adipocyte"
DOI: 10.1080/21623945.2023.2179339
Abstract: ABSTRACT While there is no standardized protocol for the differentiation of human adipocytes in culture, common themes exist in the use of supra-physiological glucose and hormone concentrations, and an absence of exogenous fatty acids. These… read more here.
Keywords: culture; adipogenesis; insulin signalling; signalling human ... See more keywords
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12610
Abstract: Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues… read more here.
Keywords: insulin signalling; insulin; peripheral tissue; lifespan ... See more keywords
Exercise ameliorates insulin resistance and improves ASK1-mediated insulin signalling in obese rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.16994
Abstract: Increasing evidence reveals that physical exercise is an efficient therapeutical approach in the treatment of insulin resistance (IR) and related metabolic diseases. However, the potential beneficial effects of exercise on insulin resistance and its underlying… read more here.
Keywords: insulin signalling; insulin; mediated insulin; ask1 mediated ... See more keywords
Hypothalamic insulin signalling as a nexus regulating mood and metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12939
Abstract: Insulin has long been known as a metabolic hormone critical in the treatment of diabetes for its peripheral effects on blood glucose. However, in the last 50 years, insulin has entered the realm of neuroendocrinology… read more here.
Keywords: insulin signalling; insulin; metabolism; hypothalamic insulin ... See more keywords
186 Reduced pericyte insulin signalling causes abnormal developmental angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Heart"
DOI: 10.1136/heartjnl-2017-311726.184
Abstract: Introduction Microvascular endothelial cells (ECs) are surrounded and supported by mural cells called pericytes. Via paracrine signalling and gap junctions, pericytes interact with ECs, modulating angiogenesis and vessel homeostasis. Diabetes-associated vascular complications are characterised by… read more here.
Keywords: insulin signalling; insulin; angiogenesis; pericyte ... See more keywords
Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-019-2742-y
Abstract: BackgroundIt has been testified that Diabetes mellitus (DM) has a close association with chronic inflammation and Toll-like Receptors (TLRs), and DM could be prevented by mulberry leaf. Therefore, a hypothesis came into being that mulberry… read more here.
Keywords: insulin signalling; insulin; mulberry leaf; signalling pathway ... See more keywords
Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113306
Abstract: In the last two decades, numerous in vitro studies demonstrated that insulin receptors and theirs downstream pathways are widely distributed throughout the brain. This evidence has proven that; at variance with previous believes; insulin/insulin-like-growth-factor (IGF)… read more here.
Keywords: insulin signalling; insulin; alzheimer disease; type diabetes ... See more keywords
Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415811
Abstract: Alzheimer’s disease (AD) and type 2 diabetes (T2D) are chronic diseases that share several pathological mechanisms, including insulin resistance and impaired insulin signalling. Their shared features have prompted the evaluation of the drugs used to… read more here.
Keywords: targeting insulin; alzheimer disease; insulin signalling; use insulin ... See more keywords
Hepatic miR-215 target Rictor and modulation of hepatic insulin signalling in rats
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DOI: 10.3892/mmr.2019.10031
Abstract: Increasing evidence has suggested that hepatic lipid accumulation is associated with hepatic insulin resistance; however, the underlying mechanism is yet to be determined. It was demonstrated that the levels of microRNA-215 (miR-215) expression in the… read more here.
Keywords: insulin signalling; insulin; hepatic insulin; target ... See more keywords