Heterogeneity in insulin-stimulated glucose uptake among different muscle groups in healthy lean people and people with obesity
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05383-w
Abstract: Aims/hypothesis It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body,… read more here.
Keywords: perfusion; muscle; fibre type; glucose uptake ... See more keywords
Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.100998
Abstract: Objective Exercise is a cornerstone in the management of skeletal muscle insulin-resistance. A well-established benefit of a single bout of exercise is increased insulin sensitivity for hours post-exercise in the previously exercised musculature. Although rodent… read more here.
Keywords: insulin; translocation; prior exercise; insulin stimulated ... See more keywords
SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20170202
Abstract: Trafficking within eukaryotic cells is a complex and highly regulated process; events such as recycling of plasma membrane receptors, formation of multivesicular bodies, regulated release of hormones and delivery of proteins to membranes all require… read more here.
Keywords: snare phosphorylation; phosphorylation control; phosphorylation; insulin stimulated ... See more keywords
Abstract 856: Mitochondrial Protein Kinase B (akt) Translocation Mediates Insulin-stimulated Cardiac Glucose Oxidation
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.856
Abstract: Introduction: Insulin stimulates glucose oxidation, an effect which is associated with simulating pyruvate dehydrogenase (PDH). However, how the insulin signal is transduced from the cell membrane to the mitochondria to stimulate PDH is not known.… read more here.
Keywords: insulin; cardiac glucose; insulin stimulated; protein kinase ... See more keywords
Gene deletion of γ‐actin impairs insulin‐stimulated skeletal muscle glucose uptake in growing mice but not in mature adult mice
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15183
Abstract: The cortical cytoskeleton, consisting of the cytoplasmic actin isoforms β and/or γ‐actin, has been implicated in insulin‐stimulated GLUT4 translocation and glucose uptake in muscle and adipose cell culture. Furthermore, transgenic inhibition of multiple actin‐regulating proteins… read more here.
Keywords: insulin stimulated; glucose uptake; muscle glucose; mice ... See more keywords
Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-21-0285
Abstract: Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metabolism… read more here.
Keywords: finnish specific; insulin stimulated; akt2; gene variant ... See more keywords
1779-P: Characterization of Insulin-Regulated CLASP2 Phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1779-p
Abstract: During an unbiased proteomics screen of rat L6 myotubes, we previously discovered the first member of the microtubule plus-end interacting protein (+TIP) family that undergoes insulin-stimulated phosphorylation, CLIP-associating protein 2 (CLASP2). Here we report that… read more here.
Keywords: insulin stimulated; phosphorylation; clasp2 phosphorylation; clasp2 protein ... See more keywords
Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0855
Abstract: Insulin-stimulated muscle glucose uptake is a key process in glycemic control. This process depends on the redistribution of glucose transporters to the surface membrane, a process that involves regulatory proteins such as TBC1D1 and TBC1D4.… read more here.
Keywords: muscle; insulin regulated; insulin stimulated; skeletal muscle ... See more keywords
25-Hydroxyvitamin D Increases Insulin-Stimulated Glucose Uptake by Enhancing Adipocyte Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.68.420
Abstract: Vitamin D and its receptor (vitamin D receptor; VDR) regulate calcium homeostasis in mammals. Recently, studies have shown that serum concentrations of 25-hydroxyvitamin D (25VD) are negatively associated with insulin resistance and the incidence of… read more here.
Keywords: expression; insulin stimulated; stimulated glucose; differentiation ... See more keywords
Erratum: The Regulation of Insulin-Stimulated Cardiac Glucose Transport via Protein Acetylation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2018.00103
Abstract: [This corrects the article DOI: 10.3389/fcvm.2018.00070.]. read more here.
Keywords: stimulated cardiac; erratum regulation; cardiac glucose; glucose transport ... See more keywords