Stage-specific expression and divergent functions of two insulinase-like proteases associated with host infectivity in Cryptosporidium
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DOI: 10.1371/journal.pntd.0012777
Abstract: Background The determinants of differences in host infectivity among Cryptosporidium species and subtypes are poorly understood. Results from recent comparative genomic studies suggest that gains and losses of multicopy subtelomeric genes encoding insulinase-like proteases (INS-19… read more here.
Keywords: like proteases; insulinase like; ins ins; infectivity ... See more keywords
Characterization of a Species-Specific Insulinase-Like Protease in Cryptosporidium parvum
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DOI: 10.3389/fmicb.2019.00354
Abstract: Cryptosporidium parvum is an intracellular protozoan that can cause severe diarrhea in humans and various mammals. Results of a comparative genomic analysis indicated that genes encoding two C. parvum-specific insulinase-like proteases (INS19 and INS20), cgd6_5510… read more here.
Keywords: cgd6; parvum; insulinase like; cryptosporidium parvum ... See more keywords
Expression and Functional Studies of INS-5, an Insulinase-Like Protein in Cryptosporidium parvum
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DOI: 10.3389/fmicb.2020.00719
Abstract: The small Cryptosporidium genome (∼9 Mb) has over 20 copies of genes encoding insulinase-like proteases (INS), suggesting that these enzymes may have important biological functions in the pathogen and could be developmentally regulated. In this… read more here.
Keywords: protein; cryptosporidium parvum; insulinase like; expression ... See more keywords