Glucose‐dependent insulinotropic polypeptide monoclonal antibodies prevent and treat obesity in wild‐type and hyperphagic mice
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23758
Abstract: This study aimed to investigate whether a glucose‐dependent insulinotropic polypeptide (GIP) monoclonal antibody (mAb) will promote weight loss in wild‐type mice and to determine effects of this mAb in preventing weight gain in ob/ob mice. read more here.
Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; mice ... See more keywords
Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170201
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin that, in common with glucagon-like peptide-1 (GLP-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. GIP is released in response to glucose or fat absorption and acts… read more here.
Keywords: insulinotropic polypeptide; islet; beta; gip ... See more keywords
Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY3-36.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.04.007
Abstract: T-2 toxin, a potent type A trichothecene mycotoxin, is produced by various Fusarium species and can negatively impact animal and human health. Although anorexia induction is a common hallmark of T-2 toxin-induced toxicity, the underlying… read more here.
Keywords: insulinotropic polypeptide; peptide yy3; toxin; dependent insulinotropic ... See more keywords
Design of novel therapeutics targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) to aid weight loss
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2203911
Abstract: ABSTRACT Introduction With obesity rates growing globally, there is a paramount need for new obesity pharmacotherapies to tackle this pandemic. Areas covered This review focuses on the design of therapeutics that target the glucose-dependent insulinotropic… read more here.
Keywords: glucose dependent; insulinotropic polypeptide; dependent insulinotropic; gipr ... See more keywords
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15894
Abstract: The incretin hormone, gastric inhibitory peptide/glucose‐dependent insulinotropic polypeptide (GIP), secreted by the enteroendocrine K‐cells in the proximal intestine, may regulate lipid metabolism and adiposity, but its exact role in these processes is unclear. read more here.
Keywords: dependent insulinotropic; insulinotropic polypeptide; polypeptide receptor; glucose dependent ... See more keywords
Glucose‐dependent insulinotropic polypeptide counteracts diet‐induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin‐responsive and proopiomelanocortin neurons in the arcuate nucleus
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.1111/dom.15001
Abstract: To clarify the effects of glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists (GIPRAs) on feeding and body weight. read more here.
Keywords: dependent insulinotropic; insulinotropic polypeptide; polypeptide counteracts; glucose dependent ... See more keywords
Glucose‐dependent insulinotropic polypeptide secretion after oral macronutrient ingestion: The human literature revisited and a systematic study in model experiments in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13836
Abstract: The incretin hormone glucose‐dependent insulinotropic polypeptide (GIP) is secreted after meal ingestion. This study explored the relative influence of classes of macronutrients on GIP secretion. read more here.
Keywords: ingestion; dependent insulinotropic; insulinotropic polypeptide; glucose dependent ... See more keywords
Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion in humans: Characteristics and regulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13962
Abstract: Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion. Their release after meal ingestion and oral glucose are… read more here.
Keywords: glucose dependent; insulinotropic polypeptide; glucagon like; secretion ... See more keywords
Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.17852
Abstract: Background: Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the precise underlying mechanism. We seek… read more here.
Keywords: glucose dependent; postural tachycardia; insulinotropic polypeptide; tachycardia ... See more keywords
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.164921
Abstract: Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics' ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored the role of… read more here.
Keywords: gipr neurons; glucose dependent; pharmacology; insulinotropic polypeptide ... See more keywords
[The "other" incretin - the therapeutic rediscovery of the glucose-dependent insulinotropic polypeptide].
Sign Up to like & getrecommendations! Published in 2023 at "Orvosi hetilap"
DOI: 10.1556/650.2023.32710
Abstract: Among the two incretins that strongly stimulate insulin secretion and are also involved in its physiological regulation in type 2 diabetes, glucagon-like peptide-1 (GLP1) has been the focus of interest for a long time, due… read more here.
Keywords: dependent insulinotropic; type diabetes; insulinotropic polypeptide; glucose dependent ... See more keywords