Rapid analysis of titer, aggregate and intact mass of antibody therapeutics using automated multi-dimensional liquid chromatography coupled with native mass spectroscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202201050
Abstract: Monoclonal antibodies are tetrameric complex proteins, primarily produced using mammalian cell culture. Attributes such as titre, aggregates, and intact mass analysis are monitored during process development/ optimization. In the present study, a novel workflow such… read more here.
Keywords: native mass; spectroscopy; analysis; intact mass ... See more keywords
Extending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE)
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2103906
Abstract: ABSTRACT Mass spectrometry (MS) has become an indispensable tool in structural characterization and quality control of monoclonal antibodies (mAbs). Intact-mass analysis is a particularly attractive option that provides a powerful and cost-effective means to not… read more here.
Keywords: capabilities intact; ige; intact mass; extending capabilities ... See more keywords