Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats.
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DOI: 10.1111/bph.70206
Abstract: Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake. However,… read more here.
Keywords: efficacy seeking; troriluzole attenuates; opioid intake; intake reinforcing ... See more keywords