System-Wide Profiling by Proteome Integral Solubility Alteration Assay of Drug Residence Times for Target Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1101/2022.06.27.497697
Abstract: Most drugs used in the clinic and drug candidates target multiple proteins, and thus detailed characterization of their efficacy targets is required. While current methods rely on quantitative measurements at thermodynamic equilibrium, kinetic parameters such… read more here.
Keywords: proteome integral; residence; solubility alteration; integral solubility ... See more keywords