Starting or Switching to an Integrase Inhibitor-Based Regimen Affects PTSD Symptoms in Women with HIV
Sign Up to like & getrecommendations! Published in 2020 at "AIDS and Behavior"
DOI: 10.1007/s10461-020-02967-2
Abstract: As the use of Integrase inhibitor (INSTI)-class antiretroviral medications becomes more common to maintain long-term viral suppression, early reports suggest the potential for CNS side-effects when starting or switching to an INSTI-based regimen. In a… read more here.
Keywords: starting switching; ptsd symptoms; integrase inhibitor; subscale ... See more keywords
CYP1A1 and 1B1‐mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.012
Abstract: &NA; Dolutegravir (DTG), a potent integrase inhibitor, is part of a recommended initial regimen for the treatment of human immunodeficiency virus (HIV). Prior reports demonstrated that the clearance of DTG was higher in current smokers… read more here.
Keywords: cyp1a1 1b1; metabolic pathways; dtg; mediated metabolic ... See more keywords
Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-0281-4
Abstract: HIV is a retrovirus that infects CD4+ T lymphocytes in human beings and causes immunodeficiency. In the recent years, various therapies have been developed against HIV, including targeting the HIV specific protein, integrase, responsible for… read more here.
Keywords: integrase; inhibitors elvitegravir; hiv; integrase inhibitor ... See more keywords
Similar plasma lipidomic profile in people living with HIV treated with a darunavir-based or an integrase inhibitor-based antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53761-7
Abstract: Cardiovascular disease is an important cause of morbidity and mortality in people living with HIV (PLWH), who commonly experience lipid disturbances. The aim of this study was to determine whether the plasma lipidomic profile differs… read more here.
Keywords: based art; lipidomic profile; inhibitor based; darunavir based ... See more keywords
Synthesis of Fused Oxepane HIV Integrase Inhibitor MK-1376
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0040-1707994
Abstract: Controlling the absolute and relative stereochemistry of a seven-membered oxepane in the formation of HIV integrase inhibitor MK-1376 was accomplished through a strategy involving the use of asymmetric allylation and stereoconvergent, substrate-directed installation of an… read more here.
Keywords: hiv integrase; inhibitor 1376; integrase inhibitor;
High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaa033
Abstract: Abstract Objectives HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with… read more here.
Keywords: integrase; hiv; prevalence; resistance ... See more keywords
Integrase Inhibitor Resistance Mechanisms and Structural Characteristics in Antiretroviral Therapy-Experienced, Integrase Inhibitor-Naive Adults with HIV-1 Infection Treated with Dolutegravir plus Two Nucleoside Reverse Transcriptase Inhibitors in the DAWNING Study
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01643-21
Abstract: At week 48 in the phase IIIb DAWNING study, the integrase strand transfer inhibitor (INSTI) dolutegravir plus 2 nucleoside reverse transcriptase inhibitors demonstrated superiority to ritonavir-boosted lopinavir in achieving virologic suppression in adults with HIV-1… read more here.
Keywords: integrase inhibitor; dawning study; integrase; resistance ... See more keywords
The Burden of Neuropsychiatric Disorders in Medicaid Patients Living With HIV-1 Treated With Integrase Inhibitor or Protease Inhibitor Antiretroviral Therapies.
Sign Up to like & getrecommendations! Published in 2023 at "The primary care companion for CNS disorders"
DOI: 10.4088/pcc.22m03374
Abstract: Objective: Data are scarce regarding the incidence of neuropsychiatric events (NPEs) in people living with human immunodeficiency virus (HIV)-1 taking integrase inhibitor (INI)- or protease inhibitor (PI)-based regimens. This study evaluated the prevalence, incidence, and… read more here.
Keywords: incidence; living hiv; inhibitor; integrase inhibitor ... See more keywords