Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-018-0684-z
Abstract: Prevention of mother-to-child transmission of HIV and optimal maternal treatment are the most important goals of antiretroviral therapy in pregnant women with HIV. These goals may be at risk due to possible reduced exposure during… read more here.
Keywords: integrase inhibitors; pharmacokinetics hiv; pregnant women; inhibitors pregnancy ... See more keywords
HIV integrase inhibitors that inhibit strand transfer interact with RAG1 and hamper its activities.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107515
Abstract: Multiple steps of the retroviral infection process have been targeted over the years to develop therapeutic approaches, starting from the entry of the virus into the cell till the viral DNA integration to host genome.… read more here.
Keywords: integrase inhibitors; inhibit strand; inhibitors inhibit; strand transfer ... See more keywords
Effectiveness and safety of integrase inhibitors in HIV-infected pregnant women followed up in the Madrid Cohort.
Sign Up to like & getrecommendations! Published in 2020 at "Medicina clinica"
DOI: 10.1016/j.medcli.2020.01.036
Abstract: INTRODUCTION The risk of HIV-1 mother-to-child transmission (MTCT) is associated mainly with gestational age at which antiretroviral therapy begins and the HIV-1 RNA plasma viral load at delivery. Regimens with integrase inhibitors (INI) are increasing… read more here.
Keywords: integrase inhibitors; pregnant women; madrid cohort; cohort ... See more keywords
Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.12.001
Abstract: The major effect of allosteric HIV integrase (IN) inhibitors (ALLINIs) is observed during virion maturation, where ALLINI treatment interrupts IN-RNA interactions via drug-induced IN aggregation, leading to the formation of aberrant virions. To understand the… read more here.
Keywords: integrase inhibitors; carboxy terminal; formation; homomeric carboxy ... See more keywords
Treatment of HIV Infections with HIV Integrase Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.6b00456
Abstract: Human immunodeficiency virus (HIV) infections and related diseases remain as major public health problems worldwide. The replication of HIV type 1 (HIV-1) requires the actions of three essential enzymes: reverse transcriptase, protease, and integrase. There… read more here.
Keywords: integrase inhibitors; infections hiv; hiv infections; hiv ... See more keywords
Comprehensive Review on Different Analytical Techniques for HIV 1- Integrase Inhibitors: Raltegravir, Dolutegravir, Elvitegravir and Bictegravir.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in analytical chemistry"
DOI: 10.1080/10408347.2022.2080493
Abstract: The advent of HIV-Integrase inhibitors (IN) has marked a significant impact on the lives of HIV patients. Since the launch of the first anti retro-viral drug "Azidothymidine" to the recent advances of IN inhibitors, about… read more here.
Keywords: analytical techniques; integrase inhibitors; review; hiv integrase ... See more keywords
Characterization of HIV-1 Integrase Gene and Resistance Associated Mutations Prior to Roll out of Integrase Inhibitors by Kenyan National HIV-Treatment Program in Kenya
Sign Up to like & getrecommendations! Published in 2020 at "Ethiopian Journal of Health Sciences"
DOI: 10.4314/ejhs.v30i1.6
Abstract: Background Antiretroviral therapy containing an integrase strand transfer inhibitor plus two Nucleoside Reverse Transcriptase inhibitors has now been recommended for treatment of HIV-1-infected patients. This thus determined possible pre-existing integrase resistance-associated mutations in the integrase… read more here.
Keywords: integrase; integrase inhibitors; kenya; hiv ... See more keywords
Latest advances in the efficacy, tolerability, and monotherapy of integrase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience trends"
DOI: 10.5582/bst.2017.01194
Abstract: More than 30 drugs for antiretroviral therapy (ART), including integrase inhibitors (INIs), have been approved by the U.S. Food and Drug Administration (FDA) as of 2017. Integrase is the third essential enzyme in the cycle… read more here.
Keywords: integrase; integrase inhibitors; latest advances; art ... See more keywords
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46344
Abstract: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking selectivity… read more here.
Keywords: integrase; pyridine based; integrase inhibitors; hiv integrase ... See more keywords