Maternal Use of Integrase Strand Transfer Inhibitors During Pregnancy and Infant Neurodevelopment
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.45652
Abstract: Key Points Question Do integrase strand transfer inhibitors (INSTIs) used as part of antiretroviral treatment (ART) by pregnant women with HIV have an adverse association with their infant’s neurodevelopment? Findings In this cohort study of… read more here.
Keywords: infant neurodevelopment; strand transfer; integrase strand; transfer inhibitors ... See more keywords
Weighing in on the Role of Integrase Strand Transfer Inhibitors (INSTIs) on Weight Gain: Fact or Fiction?
Sign Up to like & getrecommendations! Published in 2020 at "Current Infectious Disease Reports"
DOI: 10.1007/s11908-020-00727-w
Abstract: Purpose of Review The goal of this manuscript was to review the growing body of evidence examining the relationship between integrase strand inhibitors (INSTIs) and weight gain in treatment-naïve and treatment-experienced populations of people living… read more here.
Keywords: inhibitors instis; treatment; gain; integrase strand ... See more keywords
Novel secondary mutations C56S and G149A confer resistance to HIV‐1 integrase strand transfer inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.01.013
Abstract: ABSTRACT Cabotegravir (CAB, S/GSK1265744) is an investigational second‐generation integrase strand transfer inhibitor (INSTI) with a chemical structure similar to dolutegravir. CAB is under development as a long‐acting injectable formulation for treatment of HIV‐1 infection and… read more here.
Keywords: integrase; c56s g149a; strand transfer; resistance ... See more keywords
Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.08.008
Abstract: Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, the development of drug resistance… read more here.
Keywords: efficacy; strand transfer; resistance; efficacy resistance ... See more keywords
N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants
Sign Up to like & getrecommendations! Published in 2024 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.3c00525
Abstract: HIV-1 integrase (IN) is an important molecular target for the development of anti-AIDS drugs. A recently FDA-approved second-generation integrase strand transfer inhibitor (INSTI) cabotegravir (CAB, 2021) is being marketed for use in long-duration antiviral formulations.… read more here.
Keywords: integrase; cab; integrase strand; potently inhibit ... See more keywords
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2159569
Abstract: Abstract Bictegravir (BIC) is a potent small-molecule integrase strand-transfer inhibitor (INSTI) and a component of Biktarvy®, a single-tablet combination regimen that is currently approved for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.… read more here.
Keywords: transfer inhibitor; potent; integrase strand; strand transfer ... See more keywords
Integrase strand transfer inhibitors use in children with perinatal HIV-1 infection: a narrative review.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0039
Abstract: INTRODUCTION Integrase strand transfer inhibitors (INSTIs), including raltegravir (RAL), dolutegravir (DTG), elvitegravir (EVG), bictegravir (BIC), and cabotegravir (CAB), are increasingly used given excellent data on their efficacy, effectiveness, and tolerability profile in adults, while data… read more here.
Keywords: integrase strand; strand transfer; transfer inhibitors; narrative review ... See more keywords
Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac295
Abstract: Abstract Introduction Sub-Saharan African countries are introducing integrase strand transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and dolutegravir is the INSTI of choice due to its potency, tolerability and high… read more here.
Keywords: integrase strand; strand transfer; resistance; line ... See more keywords
Assessing phenotypic effect of integrase strand-transfer inhibitor (INSTI)-based resistance substitutions associated with failures on cabotegravir
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaf019
Abstract: Abstract Objectives International guidelines recommend integrase strand-transfer inhibitor (INSTI)-based regimens as initial and switch therapy in people with HIV. As novel INSTIs become available, understanding how emergence of resistance at virological failures and seroconversions affects… read more here.
Keywords: resistance; insti; integrase strand; bictegravir elvitegravir ... See more keywords
Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky497
Abstract: OBJECTIVES To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs). METHODS Patients in 18 HIV… read more here.
Keywords: adverse events; strand transfer; discontinuation; integrase strand ... See more keywords
Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy294
Abstract: Abstract Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs,… read more here.
Keywords: strand transfer; resistance; resistance integrase; integrase strand ... See more keywords