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   Articles with "integrase strand" as a keyword



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Weighing in on the Role of Integrase Strand Transfer Inhibitors (INSTIs) on Weight Gain: Fact or Fiction?

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recommendations! Published in 2020 at "Current Infectious Disease Reports"

DOI: 10.1007/s11908-020-00727-w

Abstract: Purpose of Review The goal of this manuscript was to review the growing body of evidence examining the relationship between integrase strand inhibitors (INSTIs) and weight gain in treatment-naïve and treatment-experienced populations of people living… read more here.

Keywords: inhibitors instis; treatment; gain; integrase strand ... See more keywords
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Novel secondary mutations C56S and G149A confer resistance to HIV‐1 integrase strand transfer inhibitors

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recommendations! Published in 2018 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2018.01.013

Abstract: ABSTRACT Cabotegravir (CAB, S/GSK1265744) is an investigational second‐generation integrase strand transfer inhibitor (INSTI) with a chemical structure similar to dolutegravir. CAB is under development as a long‐acting injectable formulation for treatment of HIV‐1 infection and… read more here.

Keywords: integrase; c56s g149a; strand transfer; resistance ... See more keywords
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Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors.

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recommendations! Published in 2019 at "International journal of antimicrobial agents"

DOI: 10.1016/j.ijantimicag.2019.08.008

Abstract: Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, the development of drug resistance… read more here.

Keywords: efficacy; strand transfer; resistance; efficacy resistance ... See more keywords
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Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection

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recommendations! Published in 2022 at "Xenobiotica"

DOI: 10.1080/00498254.2022.2159569

Abstract: Abstract Bictegravir (BIC) is a potent small-molecule integrase strand-transfer inhibitor (INSTI) and a component of Biktarvy®, a single-tablet combination regimen that is currently approved for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.… read more here.

Keywords: transfer inhibitor; potent; integrase strand; strand transfer ... See more keywords
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Integrase strand transfer inhibitors use in children with perinatal HIV-1 infection: a narrative review.

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recommendations! Published in 2022 at "AIDS research and human retroviruses"

DOI: 10.1089/aid.2022.0039

Abstract: INTRODUCTION Integrase strand transfer inhibitors (INSTIs), including raltegravir (RAL), dolutegravir (DTG), elvitegravir (EVG), bictegravir (BIC), and cabotegravir (CAB), are increasingly used given excellent data on their efficacy, effectiveness, and tolerability profile in adults, while data… read more here.

Keywords: integrase strand; strand transfer; transfer inhibitors; narrative review ... See more keywords
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Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania

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recommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dkac295

Abstract: Abstract Introduction Sub-Saharan African countries are introducing integrase strand transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and dolutegravir is the INSTI of choice due to its potency, tolerability and high… read more here.

Keywords: integrase strand; strand transfer; resistance; line ... See more keywords
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Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort

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recommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dky497

Abstract: OBJECTIVES To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs). METHODS Patients in 18 HIV… read more here.

Keywords: adverse events; strand transfer; discontinuation; integrase strand ... See more keywords
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Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient

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recommendations! Published in 2018 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofy294

Abstract: Abstract Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs,… read more here.

Keywords: strand transfer; resistance; resistance integrase; integrase strand ... See more keywords
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Resistance in Patients Failing Integrase Strand Transfer Inhibitors: A Call to Replace Raltegravir With Dolutegravir in Third-Line Treatment in South Africa

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recommendations! Published in 2019 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofz377

Abstract: Abstract Data on integrase resistance patterns in low- and middle-income countries (LMICs) is scarce. We assessed genotypic drug resistance in 43 patients with virological failure on integrase strand transfer inhibitors (INSTIs) containing regimens as part… read more here.

Keywords: integrase; resistance patients; strand transfer; transfer inhibitors ... See more keywords
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Mutations in the HIV-1 3′-Polypurine Tract and Integrase Strand Transfer Inhibitor Resistance

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recommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02432-20

Abstract: Integrase strand-transfer inhibitors (INSTIs), in combination with other antivirals, are widely used for the treatment of HIV-1-infected individuals. HIV-1 resistance to INSTIs is typically associated with mutations in the viral integrase gene [1].…. read more here.

Keywords: integrase strand; strand transfer; resistance;

Integrase Strand Transfer Inhibitors and the Emergence of Immune Reconstitution Inflammatory Syndrome (IRIS).

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recommendations! Published in 2017 at "Current HIV research"

DOI: 10.2174/1570162x15666171122155708

Abstract: BACKGROUND Immune reconstitution inflammatory syndrome (IRIS) is a major concern when starting highly active anti-retroviral therapy (HAART) in new patients and especially late presenters. This study attempts to identify risk factors for IRIS and investigate… read more here.

Keywords: syndrome iris; inflammatory syndrome; reconstitution inflammatory; integrase strand ... See more keywords