Integrated computational intelligent paradigm for nonlinear electric circuit models using neural networks, genetic algorithms and sequential quadratic programming
Sign Up to like & getrecommendations! Published in 2019 at "Neural Computing and Applications"
DOI: 10.1007/s00521-019-04573-3
Abstract: In this paper, a novel application of biologically inspired computing paradigm is presented for solving initial value problem (IVP) of electric circuits based on nonlinear RL model by exploiting the competency of accurate modeling with… read more here.
Keywords: paradigm; genetic algorithms; sequential quadratic; circuit ... See more keywords
Identifying Structure–Property Relationships Through DREAM.3D Representative Volume Elements and DAMASK Crystal Plasticity Simulations: An Integrated Computational Materials Engineering Approach
Sign Up to like & getrecommendations! Published in 2017 at "JOM"
DOI: 10.1007/s11837-017-2303-0
Abstract: Predicting, understanding, and controlling the mechanical behavior is the most important task when designing structural materials. Modern alloy systems—in which multiple deformation mechanisms, phases, and defects are introduced to overcome the inverse strength–ductility relationship—give raise… read more here.
Keywords: representative volume; materials engineering; integrated computational; approach ... See more keywords
Modeling Early-Stage Processes of U-10 Wt.%Mo Alloy Using Integrated Computational Materials Engineering Concepts
Sign Up to like & getrecommendations! Published in 2017 at "JOM"
DOI: 10.1007/s11837-017-2608-z
Abstract: Low-enriched uranium alloyed with 10 wt.% molybdenum (U-10Mo) has been identified as a promising alternative to high-enriched uranium. Manufacturing U-10Mo alloy involves multiple complex thermomechanical processes that pose challenges for computational modeling. This paper describes… read more here.
Keywords: materials engineering; integrated computational; stage processes; early stage ... See more keywords
Integrated Computational Materials Engineering in Solar Plants: The Virtual Materials Design Project
Sign Up to like & getrecommendations! Published in 2018 at "JOM"
DOI: 10.1007/s11837-018-2970-5
Abstract: The high temperatures required for efficient operation of solar thermal power plants constitutes one of the major challenges of this technology. Gaining insight into materials behavior at very high temperatures is critical to improve their… read more here.
Keywords: materials engineering; solar plants; engineering solar; integrated computational ... See more keywords
Integrated Computational Materials Engineering to Predict Melt-Pool Dimensions and 3D Grain Structures for Selective Laser Melting of Inconel 625
Sign Up to like & getrecommendations! Published in 2019 at "Integrating Materials and Manufacturing Innovation"
DOI: 10.1007/s40192-019-00145-4
Abstract: This work presents a comparison of simulation results with the experimental data for four of the six challenges within the National Institute of Standards and Technology (NIST) Additive Manufacturing (AM) Benchmark Test Series (AM Bench)… read more here.
Keywords: materials engineering; melt pool; integrated computational; geometry ... See more keywords
Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c00296
Abstract: Leucine-zipper transcription regulator 1 (LZTR1) is a highly mutated tumor suppressor gene, involved in the pathogenesis of several cancer types and developmental disorders. In proteasomal degradation, it acts as an adaptor protein responsible for the… read more here.
Keywords: protein; computational approach; recruitment; integrated computational ... See more keywords
Structure of the stress-related LHCSR1 complex determined by an integrated computational strategy
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03083-8
Abstract: Light-harvesting complexes (LHCs) are pigment-protein complexes whose main function is to capture sunlight and transfer the energy to reaction centers of photosystems. In response to varying light conditions, LH complexes also play photoregulation and photoprotection… read more here.
Keywords: computational strategy; stress related; lhcsr1; integrated computational ... See more keywords
An integrated computational approach to screening of alkaloids inhibitors of TBX3 in breast cancer cell lines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2046166
Abstract: Abstract TBX3 is an ancient and evolutionarily conserved family member of T-box transcription factors that acts as a key regulator in embryonic development and organogenesis. It is often overexpressed in various epithelial and mesenchymal malignancies… read more here.
Keywords: integrated computational; inhibitors tbx3; development; breast cancer ... See more keywords
An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab338
Abstract: Protein engineering and design principles employing the 20 standard amino acids have been extensively used to achieve stable protein scaffolds and deliver their specific activities. Although this confers some advantages, it often restricts the sequence,… read more here.
Keywords: affinity; nanobody; computational pipeline; integrated computational ... See more keywords
Integrated Computational and Experimental Discovery of a Promising Xanthine Derivative with Anticancer Potential Targeting EGFR.
Sign Up to like & getrecommendations! Published in 2025 at "Current cancer drug targets"
DOI: 10.2174/0115680096363027250731042338
Abstract: INTRODUCTION Epidermal Growth Factor Receptor (EGFR) is a well-established therapeutic target in cancer treatment. In this study, a novel N-phenylacetamide derivative of theobromine, designated as T-1-PA, was designed as a potential semisynthetic EGFR inhibitor. METHOD… read more here.
Keywords: egfr; cancer; egfr inhibition; integrated computational ... See more keywords
Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2025.1622511
Abstract: Non-small cell lung cancer (NSCLC) remains a significant clinical challenge, necessitating exploration of novel therapeutic targets such as TIM-3. In this study, integrated computational and experimental methods were utilized to identify potent TIM-3 inhibitors. Survival… read more here.
Keywords: pyrazolo pyridin; integrated computational; computational experimental; triazol phenyl ... See more keywords