Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2018.08.021
Abstract: Summary Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating… read more here.
Keywords: pharmacodynamic analysis; integrated pharmacodynamic; metformin; breast cancer ... See more keywords
Decoding multicomponent crosstalk: integrated pharmacodynamic‒pharmacokinetic network of sour jujube seed
Sign Up to like & getrecommendations! Published in 2025 at "Chinese Medicine"
DOI: 10.1186/s13020-025-01265-0
Abstract: Ziziphus jujuba var. spinosa seed (SJS) is a multicomponent traditional remedy with diverse pharmacological activities, including sedative, neuroprotective, anxiolytic, and cardiometabolic effects. However, identifying the bioactive constituents responsible for these broad therapeutic effects and understanding… read more here.
Keywords: pharmacodynamic pharmacokinetic; seed; pharmacokinetic network; integrated pharmacodynamic ... See more keywords