Integrated Proteomics and Metabolomics Reveal the Mechanism of Nephrotoxicity Induced by Triptolide.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00091
Abstract: Triptolide (TP), the main active ingredient of Tripterygium wilfordii Hook F., has great potential in the treatment of autoimmune diseases. However, it has been found that the side effects of TP involve multiple organs and… read more here.
Keywords: mechanism; proteomics metabolomics; metabolism; integrated proteomics ... See more keywords
Integrated Proteomics and Metabolomics Analysis Correlative Metabolite-Protein Networks in Soybean Seeds Subjected to Warm-Water Soaking.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c00986
Abstract: Soaking of soybean seeds is prerequisite for the production of soy foods and it has been shown that the extent of water absorbed during different imbibition conditions directly affects the quality of the subsequent soybean… read more here.
Keywords: seed; proteomics metabolomics; soybean seeds; water ... See more keywords
Integrated proteomics and metabolomics analysis of transgenic and gene-stacked maize line seeds
Sign Up to like & getrecommendations! Published in 2021 at "GM Crops & Food"
DOI: 10.1080/21645698.2021.1934351
Abstract: ABSTRACT Unintended effects of genetically modified (GM) crops may pose safety issues. Omics techniques provide researchers with useful tools to assess such unintended effects. Proteomics and metabolomics analyses were performed for three GM maize varieties,… read more here.
Keywords: zheng58 zheng58; proteomics metabolomics; analysis; integrated proteomics ... See more keywords
Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321448
Abstract: Background: Signaling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling has served as the prototypical system to elucidate cAMP compartmentalization. Although studies in cardiac myocytes have… read more here.
Keywords: camp nanodomains; camp; integrated proteomics; cardiac myocyte ... See more keywords
An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00370
Abstract: Drastic macrophages activation triggered by exogenous infection or endogenous stresses is thought to be implicated in the pathogenesis of various inflammatory diseases. Carnosic acid (CA), a natural phenolic diterpene extracted from Salvia officinalis plant, has… read more here.
Keywords: anti inflammatory; mechanism; bioinformatics approach; proteomics bioinformatics ... See more keywords
Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways
Sign Up to like & getrecommendations! Published in 2025 at "Antioxidants"
DOI: 10.3390/antiox14070861
Abstract: Sperm freezability exhibits marked individual variability, yet the mechanisms remain unclear. Using bulls as the experimental model, we integrated proteomic (sperm) and metabolomic (seminal plasma) analyses of high-freezability (HF) and control (CF) bulls to identify… read more here.
Keywords: integrated proteomics; freezability; seminal plasma; post thaw ... See more keywords